In vitro activity of mastoparan-AF alone and in combination with clinically used antibiotics against multiple-antibiotic-resistant Escherichia coli isolates from animals

Peptides
Chun-Hsien LinWu-Chun Tu

Abstract

The in vitro activity of mastoparan-AF, an amphipathic antimicrobial peptide isolated from the hornet venom of Vespa affinis, alone and in combination with various clinically used antibiotics, was investigated against 21 Escherichia coli isolates/strains. Most E. coli isolates tested were detected containing multiple-antimicrobial resistance genes. Antimicrobial activity of mastoparan-AF was measured by MIC, MBC, time-kill kinetic assay and chequerboard titration method. Mastoparan-AF exhibited potent antimicrobial activity against most multiple-antibiotic-resistant E. coli isolates at the concentrations ranging from 4 to 16 μg/ml. Combination studies showed that mastoparan-AF acts synergistically with certain antibiotics, i.e., cephalothin or gentamicin, against some multiple-antibiotic-resistant E. coli isolates. In conclusion, mastoparan-AF alone or in combination with other antibiotics could be promising as alternatives for combating multiple-antibiotic-resistant E. coli in future clinical applications.

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Citations

Oct 5, 2019·Expert Opinion on Drug Delivery·Kimia KardaniAzam Bolhassani
Mar 4, 2020·Current Topics in Medicinal Chemistry·Jiarui LiEster Boix
Jun 20, 2014·Biomedical Reports·Elżbieta GrześkGrzegorz Grześk
Mar 22, 2014·Biomedical Reports·Grzegorz GrześkKatarzyna Szadujkis-Szadurska
Mar 2, 2016·PloS One·Rogerio Coutinho das NevesAna Paula Junqueira-Kipnis

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