In vitro activity of meropenem against ciprofloxacin-resistant enterobacteriaceae and Pseudomonas aeruginosa

Journal of Chemotherapy
J A García-RodríguezI Trujillano Martín

Abstract

The in-vitro susceptibilities of a total of 174 ciprofloxacin-resistant Enterobacteriaceae and Pseudomonas aeruginosa were determined. According to the BSAC and NCCLS breakpoints, meropenem, aztreonam, ceftibuten, ceftazidime, imipenem and cefotaxime were the most active (> 90%) antimicrobial agents tested against Enterobacteriaceae. Susceptibility of these strains to piperacillin/tazobactam, cefpodoxime and cefixime (84.96%) was higher than that to tobramycin, gentamicin and fosfomycin (50-75%). More than 90% of P. aeruginosa were susceptible to meropenem when both interpretative susceptibility breakpoint criteria were used. Piperacillin, piperacillin/tazobactam and ceftazidime were active against 50-75% of the same strains. Meropenem was the most active antimicrobial tested against all ciprofloxacin-resistant clinical isolates assayed.

References

Aug 1, 1990·The Journal of Antimicrobial Chemotherapy·E YourassowskyF Crokaert
Jan 1, 1995·The Journal of Antimicrobial Chemotherapy·D LivingstoneR Wise
Oct 1, 1994·The Journal of Antimicrobial Chemotherapy·K Poole
Oct 1, 1993·The Journal of Antimicrobial Chemotherapy·T AlarcónL J Piddock

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Citations

Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M.O. HussonM.H. Nicolas
Mar 6, 2009·International Journal of Antimicrobial Agents·N RavanelM Maurin

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