In vitro activity of nystatin compared with those of liposomal nystatin, amphotericin B, and fluconazole against clinical Candida isolates.

Journal of Clinical Microbiology
Sevtap ArikanJ H Rex

Abstract

We investigated the in vitro activity of nystatin and liposomal nystatin against 103 Candida isolates to determine the effect of both time and medium on MICs. We also compared the nystatin MICs with those of amphotericin B and fluconazole. Testing was performed in accordance with the National Committee for Clinical Laboratory Standards M27-A microdilution methodology with RPMI 1640, RPMI 1640 supplemented with glucose to 2% (RPMI-2), and antibiotic medium 3 supplemented with glucose to 2% (AM3). While nystatin MICs were similar to or slightly lower than liposomal nystatin MICs in RPMI 1640 and RPMI-2, they were markedly higher than liposomal nystatin MICs in AM3. Use of AM3 and determination of the MIC after 24 h of incubation provided a slightly wider range of liposomal nystatin MICs (0.06 to >16 microg/ml). Under these conditions, the MICs at which 90% of isolates were inhibited of nystatin and liposomal nystatin were 2 and 1 microg/ml, respectively. Nystatin and liposomal nystatin in general showed good activity against all Candida spp. tested. Although the MICs of nystatin and liposomal nystatin tended to rise in parallel with the amphotericin B MICs, nystatin and liposomal nystatin MICs of 1 to 2 and 0.5 to 1 microg/ml, re...Continue Reading

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Citations

Dec 4, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Apr 14, 2012·The Journal of Antimicrobial Chemotherapy·Rita SemisEsther Segal
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Fritz OffnerUNKNOWN EORTC Invasive Fungal Infections Group
Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meysam MobasheriMahmoud Reza Jaafari
Aug 24, 2013·Journal of Pharmaceutical Sciences·Deiry Marín-QuinteroAlfonso Del Pozo-Carrascosa
Jan 9, 2015·Pharmaceutical Development and Technology·Catarina Pinto ReisPatrícia Rijo
Aug 8, 2007·Chemistry and Physics of Lipids·Katarzyna Hac-WydroPatrycja Dynarowicz-Łatka
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Jul 2, 2005·Expert Opinion on Emerging Drugs·Sevtap Arikan, John H Rex
May 1, 2015·BMC Oral Health·Ricardo Dias de CastroAlessandro Leite Cavalcanti
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Sep 12, 2006·Colloids and Surfaces. B, Biointerfaces·Katarzyna Hac-Wydro, Patrycja Dynarowicz-Łatka

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