In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile.

Antimicrobial Agents and Chemotherapy
James A KarlowskyGeorge G Zhanel

Abstract

Agar dilution antimicrobial susceptibility testing (CLSI, M11-A7, 2007) performed for 208 toxin-producing clinical isolates of Clostridium difficile resulted in OPT-80 MICs ranging from 0.06 to 1 microg/ml, with 90% of the isolates inhibited by a concentration of 0.5 microg/ml. The in vitro activity of OPT-80 was independent of the susceptibilities of isolates to nine other antimicrobial agents.

References

Oct 1, 1977·Journal of Bacteriology·A L SonensheinS H Fisher
Jul 1, 1975·The Journal of Antibiotics·S SergioF Parenti
Mar 3, 1975·Biochemical and Biophysical Research Communications·M TalpaertL Clerici
Jun 1, 1991·Antimicrobial Agents and Chemotherapy·R N SwansonJ J Clement
Mar 1, 1980·Journal of Virology·M S Osburne, A L Sonenshein
Feb 1, 1995·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·UNKNOWN Hospital Infection Control Practices Advisory Committee (HICPAC)
Jan 27, 1994·The New England Journal of Medicine·C P KellyJ T LaMont
Jan 11, 2001·The Journal of Antimicrobial Chemotherapy·J WiströmB Svenungsson
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J Baron
Jan 5, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorraine KyneCiarán P Kelly
May 25, 2004·Antimicrobial Agents and Chemotherapy·Grit AckermannArne C Rodloff
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·Kim L Credito, Peter C Appelbaum
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Sydney M FinegoldMauricio Bolaños
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherRichard J Hamill
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacques PepinClaude Bourassa
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Maxime GualtieriLionel Bastide
May 18, 2006·Emerging Infectious Diseases·L Clifford McDonaldDaniel B Jernigan
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Anne-Marie BourgaultUNKNOWN CDAD-CSI Study Group
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Janet F Hindler
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John G Bartlett, Dale N Gerding

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Citations

Sep 25, 2010·Applied Microbiology and Biotechnology·Stefano DonadioDaniela Jabes
Feb 4, 2011·The New England Journal of Medicine·Thomas J LouieUNKNOWN OPT-80-003 Clinical Study Group
Dec 14, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anilrudh A Venugopal, Stuart Johnson
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellie J C GoldsteinDiane M Citron
Sep 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Derrick W CrookUNKNOWN Study 003/004 Teams
Aug 7, 2012·The Journal of Antimicrobial Chemotherapy·Alan P Johnson, Mark H Wilcox
Dec 3, 2011·Current Opinion in Gastroenterology·Andrea Lo Vecchio, George M Zacur
Sep 10, 2009·Current Opinion in Infectious Diseases·Martijn P BauerEd J Kuijper
May 23, 2012·Current Opinion in Infectious Diseases·Sarah Tschudin-SutterTrish M Perl
Jun 29, 2011·Antimicrobial Agents and Chemotherapy·Farah BabakhaniPamela Sears
Nov 16, 2012·Therapeutic Advances in Gastroenterology·Yoav Golan, Lauren Epstein
Dec 7, 2011·Drugs·Sean T Duggan
Apr 26, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Rebecca F ChhimMichael L Christensen
May 12, 2010·Expert Review of Anti-infective Therapy·Dhara ShahKevin W Garey
May 21, 2013·Expert Opinion on Pharmacotherapy·Christopher J Hostler, Luke F Chen
May 8, 2010·Expert Opinion on Pharmacotherapy·Mark Miller
Jun 5, 2010·Expert Opinion on Investigational Drugs·Hoonmo L KooHerbert L Dupont
Jan 23, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyuki KunishimaMitsuo Kaku
Nov 7, 2012·Mayo Clinic Proceedings·Sahil Khanna, Darrell S Pardi
Sep 20, 2011·Pharmacotherapy·Jennifer S Hardesty, Paul Juang
Feb 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J FreemanUNKNOWN Pan-European Longitudinal Surveillance of Antibiotic Resistance among Prevalent Clostridium difficile Ribotypes' Study Group
Nov 1, 2012·Natural Product Reports·William Erb, Jieping Zhu
Sep 20, 2012·American Journal of Therapeutics·Josmi JosephSury Anand
Sep 26, 2013·Journal of Pharmacy Practice·Paul Juang, Jennifer S Hardesty
Mar 4, 2014·Therapeutic Advances in Gastroenterology·Sahil Khanna, Darrell S Pardi
Jul 5, 2015·Journal of Intensive Care Medicine·Samuel HanRandall Pellish
Jul 28, 2020·Future Microbiology·Andrew M SkinnerLarry K Kociolek
Jan 15, 2010·The Annals of Pharmacotherapy·Karyn M Sullivan, Linda M Spooner
Nov 19, 2021·Journal of the Pediatric Infectious Diseases Society·Anne J Gonzales-LunaKevin W Garey

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