In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species

Antimicrobial Agents and Chemotherapy
Jin ShiYu Pang

Abstract

In this study, we demonstrate that PBTZ169 exhibits significant differences in in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for in vitro susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the Mycobacterium fortuitum mutants.

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Citations

Dec 4, 2019·Antimicrobial Agents and Chemotherapy·Wenzhu DongJie Lu
Mar 11, 2020·The Journal of Antibiotics·Mark S Butler, David L Paterson
Apr 7, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Shu'an WenYu Pang
Nov 17, 2020·European Journal of Medicinal Chemistry·Pankaj S GiraseRajshekhar Karpoormath
Feb 2, 2021·European Journal of Medicinal Chemistry·Phelelisiwe S DubeRichard M Beteck
Mar 2, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jun WangYu Pang

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