PMID: 30150479DOI: 10.1128/aac.01314-18Aug 29, 2018Paper
In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species
Antimicrobial Agents and Chemotherapy
Jin ShiYu Pang
Abstract
In this study, we demonstrate that PBTZ169 exhibits significant differences in in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for in vitro susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the Mycobacterium fortuitum mutants.
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Citations
Dec 4, 2019·Antimicrobial Agents and Chemotherapy·Wenzhu DongJie Lu
Mar 11, 2020·The Journal of Antibiotics·Mark S Butler, David L Paterson
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Nov 17, 2020·European Journal of Medicinal Chemistry·Pankaj S GiraseRajshekhar Karpoormath
Feb 2, 2021·European Journal of Medicinal Chemistry·Phelelisiwe S DubeRichard M Beteck
Mar 2, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jun WangYu Pang
Jun 3, 2021·Pharmaceuticals·Klaudia T AngulaRichard M Beteck
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