In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis

Peptides
Lanfranco FattoriniGraziella Orefici

Abstract

The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.

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Citations

Mar 5, 2008·Antimicrobial Agents and Chemotherapy·Queenie C K CheungJulang Li
Sep 24, 2008·Journal of Dental Research·G DiamondL K Ryan
Feb 7, 2016·Biochimica Et Biophysica Acta·Thomas Gutsmann
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Jul 6, 2010·Peptides·John G RoutsiasAthanassios Tsakris
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Jun 27, 2008·Developmental and Comparative Immunology·Yongming Sang, Frank Blecha
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Sep 14, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sutharsana YathursanVijayalekshmi Sarojini
Jan 30, 2020·International Journal of Immunogenetics·Luis Antonio Cruz DíazErnesto Prado Montes de Oca
Sep 1, 2017·Applied Microbiology and Biotechnology·Richa SharmaIndu Verma
Nov 23, 2017·Frontiers in Immunology·Javier Arranz-TrullénEster Boix
May 28, 2019·Frontiers in Oncology·Santosh K GhoshAaron Weinberg
Jun 27, 2019·Current Protein & Peptide Science·Sara Silva, Nuno Vale
Dec 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saad AlghamdiSabi Ur Rehman
May 1, 2021·Pharmaceuticals·Gabriel S OliveiraCátia Teixeira

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