PMID: 9449281Feb 4, 1998Paper

In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy
F SifaouiL Gutmann

Abstract

Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, < or =1 microg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in the more resistant isolates seemed to be the essential penicillin-binding proteins for imipenem and sanfetrinem.

References

Mar 1, 1989·The Journal of Antimicrobial Chemotherapy·D Jabes, A Tomasz
Aug 1, 1985·The Journal of Infectious Diseases·H H Liu, A Tomasz
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·E Di ModugnoL Xerri
Aug 11, 1994·The New England Journal of Medicine·I R Friedland, G H McCracken
Sep 1, 1996·Antimicrobial Agents and Chemotherapy·K V SinghB E Murray

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