PMID: 8611198Mar 1, 1996Paper

In vitro activity of six macrolides, clindamycin and tetracycline on Streptococcus pneumoniae with different penicillin susceptibilities

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
R L PoulsenN Frimodt-Møller

Abstract

A collection of 99 clinical isolates of Streptococcus pneumoniae, chosen due to their different susceptibilities to penicillin, were investigated with respect to their susceptibility to the macrolides azithromycin, clarithromycin, dirithromycin, erythromycin, roxithromycin, spiramycin, and to clindamycin and tetracycline by the agar dilution method. We found complete cross resistance among the macrolides. The pneumococci were either susceptible, MIC < or = 0.5 micrograms/ml, or resistant, MIC > or = 16 micrograms/ml, to the tested macrolides, giving a bimodal distribution. In addition, complete cross resistance was observed between clindamycin and macrolides. Pneumococci resistant to macrolides were also resistant to tetracycline, and 26% of the macrolide-susceptible strains were tetracycline resistant.

References

Jul 1, 1992·The Journal of Antimicrobial Chemotherapy·T J NealK D Allen
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Citations

Jun 4, 2002·Clinical Pediatrics·Avinash K Shetty

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