PMID: 1409249May 1, 1992

In vitro activity of sulphimidazole alone and in association with trimethoprim against enteric pathogens

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M CastelliI Galatulas

Abstract

Sulphimidazole is a new sulphonamide belonging to the class of intestinal sulphonamides and characterized by the fact that it is active even in vitro. It has the heterocyclic ring of 5-nitroimidazoles on amidic nitrogen. Its antibacterial activity is similar to that of the classical sulphonamides but differs in that it also combats certain anaerobic bacteria such as Clostridium botulinum. This effect is completely absent in the case of sulphadiazine and sulphamethoxazole. Also, since p-amino-benzene-sulphonamide is present in the molecule, the drug acts in synergism with trimethoprim against certain aerobic or facultative strains of enteric pathogens.

References

Effect of trimethoprim on the occurrence of drug-resistant coliform bacteria in the faecal flora

Jan 1, 1976·Chemotherapy·A ToivanenP Toivanen

Pathogenesis and diagnosis of bacterial diarrhea

Mar 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Ashkenazi, L K Pickering

The effect of a combined preparation of trimethoprim and sulphamethoxazole following short-term and long-term administration on the flora of the human gut

Jan 1, 1973·Chemotherapy·H Knothe

Shiga bacillus dysentery

Sep 1, 1970·The Journal of Infectious Diseases·P S Brachman

Faecal flora after prolonged co-trimoxazole treatment

Aug 12, 1972·British Medical Journal·D C Speller, D M Bruten

Antibiotics in the treatment of gastroenteritis caused by enteropathogenic Escherichia coli

Jan 1, 1980·The Journal of Infectious Diseases·A ThorénD Habte

Trimethoprim in enteric fever

Jan 31, 1981·British Medical Journal·M W McKendrickI D Farrell

Citations

'In vitro' study of chemotherapeutic activity of sulphimidazole on some sensitive and metronidazole-resistant Trichomonas vaginalis strains

Nov 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M MalagoliM Castelli

Cytotoxicity and probable mechanism of action of sulphimidazole

Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·M CastelliG Baggio

Related Concepts

1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole
Bacteria, Anaerobic
Clostridium
Drug Augmentation
Paracolobactrum
Fungus Drug Sensitivity Tests
Nitroimidazoles
Pseudomonas aeruginosa
Staphylococcus aureus
Sulfonamides

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Related Papers

Cytotoxicity and probable mechanism of action of sulphimidazole

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The Journal of Antimicrobial Chemotherapy
M CastelliG Baggio
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