PMID: 1409249May 1, 1992

In vitro activity of sulphimidazole alone and in association with trimethoprim against enteric pathogens

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
M CastelliI Galatulas

Abstract

Sulphimidazole is a new sulphonamide belonging to the class of intestinal sulphonamides and characterized by the fact that it is active even in vitro. It has the heterocyclic ring of 5-nitroimidazoles on amidic nitrogen. Its antibacterial activity is similar to that of the classical sulphonamides but differs in that it also combats certain anaerobic bacteria such as Clostridium botulinum. This effect is completely absent in the case of sulphadiazine and sulphamethoxazole. Also, since p-amino-benzene-sulphonamide is present in the molecule, the drug acts in synergism with trimethoprim against certain aerobic or facultative strains of enteric pathogens.

References

Mar 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Ashkenazi, L K Pickering
Sep 1, 1970·The Journal of Infectious Diseases·P S Brachman
Aug 12, 1972·British Medical Journal·D C Speller, D M Bruten
Jan 1, 1980·The Journal of Infectious Diseases·A ThorénD Habte
Jan 31, 1981·British Medical Journal·M W McKendrickI D Farrell

Citations

Nov 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M MalagoliM Castelli
Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·M CastelliG Baggio

Related Concepts

1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole
Bacteria, Anaerobic
Clostridium
Drug Augmentation
Paracolobactrum
Fungus Drug Sensitivity Tests
Nitroimidazoles
Pseudomonas aeruginosa
Staphylococcus aureus
Sulfonamides

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