In vitro activity of sulphonamides as a function of their molar refractivity

Chemotherapy
R KaliszanK Kobylczyk

Abstract

A significnat correlation has been found between the in vitro activity of 16 commonly employed sulphonamides and their molar refractivity. The molar refractivity has been shown to be a superior parameter for the description of the activity of sulphonamides than the sum of electronegativities of atoms making up a heterocyclic substituent in the sulphonamide molecule and molecular weight of the substituent.

Citations

Sep 26, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·J FliegerM Tatarczak

Related Concepts

Alkalescens-Dispar Group
Fungus Drug Sensitivity Tests
Regression Analysis
Structure-Activity Relationship
Sulfanilamides
Sulfonamides

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