In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?

Antimicrobial Agents and Chemotherapy
Daniel GolparianMagnus Unemo

Abstract

Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.

References

Apr 4, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takashi DeguchiShin-Ichi Maeda
Apr 20, 2007·The New England Journal of Medicine·David B Ross
Oct 24, 2007·Emerging Infectious Diseases·Shigeaki YokoiShin-ichi Maeda
Jun 17, 2008·The Journal of Antimicrobial Chemotherapy·Helen M PalmerJayshree Dave
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Pennan M Barry, Jeffrey D Klausner
Apr 10, 2009·The Journal of Antimicrobial Chemotherapy·S StarninoUNKNOWN Neisseria gonorrhoeae Italian Study Group
May 27, 2009·The Journal of Antimicrobial Chemotherapy·S A ChisholmC A Ison
Sep 9, 2009·Expert Review of Anti-infective Therapy·John W TapsallMagnus Unemo
Dec 22, 2009·Diagnostic Microbiology and Infectious Disease·Shannon D PutnamRonald N Jones
Dec 30, 2009·Antimicrobial Agents and Chemotherapy·Patricia M RoblinMargaret R Hammerschlag
Feb 4, 2010·Antimicrobial Agents and Chemotherapy·Patricia G GalarzaJulio A Vázquez
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Leah N WoosleyRonald N Jones
Jun 30, 2010·Antimicrobial Agents and Chemotherapy·Stephanie A ChisholmCatherine A Ison
Jul 14, 2010·Antimicrobial Agents and Chemotherapy·Douglas J BiedenbachRonald N Jones
Jul 27, 2010·Sexually Transmitted Infections·David A Lewis
Sep 22, 2011·Sexually Transmitted Diseases·Irene MartinUNKNOWN Canadian Public Health Laboratory Network
Oct 15, 2011·International Journal of STD & AIDS·C BignellUNKNOWN British Association for Sexual Health and HIV UK
Dec 21, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan R KatzKing K Holmes
Jan 14, 2012·Annals of the New York Academy of Sciences·Magnus Unemo, William M Shafer

❮ Previous
Next ❯

Citations

Jun 15, 2013·The Lancet Infectious Diseases·David J M Wright, Berge Azadian
Sep 5, 2013·The Journal of Antibiotics·Mark S ButlerMatthew A Cooper
Dec 13, 2012·Future Microbiology·Magnus Unemo, Robert A Nicholas
Feb 28, 2014·Future Microbiology·Paula Bianca BlomquistBambos M Charalambous
Feb 5, 2014·The Journal of Antimicrobial Chemotherapy·Nerteley QuayeCatherine A Ison
Dec 23, 2015·Expert Review of Anti-infective Therapy·Hyukmin LeeYunsop Chong
Jun 1, 2012·Expert Opinion on Pharmacotherapy·Juliet E Stoltey, Pennan M Barry
Apr 25, 2015·Expert Opinion on Emerging Drugs·Magnus Unemo, William M Shafer
Feb 25, 2014·Clinics in Dermatology·Mihael Skerlev, Ivana Čulav-Košćak
Feb 26, 2013·La Presse médicale·Johan ChanalNicolas Dupin
Sep 8, 2015·Pharmacotherapy·Jason W LancasterKenneth R Lawrence
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah Kidd, Kimberly A Workowski
Jun 20, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edward W HookPrabhavathi Fernandes
Dec 30, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Prabhavathi Fernandes, David Oldach
Oct 10, 2013·Sexually Transmitted Infections·Catherine A IsonMagnus Unemo
Jun 30, 2016·The Journal of Antibiotics·Mark S ButlerMatthew A Cooper
Jan 11, 2017·Nature Reviews. Urology·Magnus Unemo, Jorgen S Jensen
May 12, 2017·Journal of Pharmacy Practice·Alexandra M MancusoJudianne Slish
Mar 28, 2018·Infection and Immunity·Zhemin WangStijn van der Veen
Dec 16, 2016·Clinical Microbiology Reviews·Emma L SweeneyChristine L Knox
May 4, 2016·Antimicrobial Agents and Chemotherapy·Mamun-Ur RashidCarl Erik Nord
Jul 2, 2014·Clinical Microbiology Reviews·Magnus Unemo, William M Shafer
Apr 15, 2015·Antimicrobial Agents and Chemotherapy·Brian D JamiesonPrabhavathi Fernandes
Oct 3, 2018·Antimicrobial Agents and Chemotherapy·Jonathan D LenzJoseph P Dillard
Apr 23, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael J BuegeSamuel L Aitken
Feb 11, 2014·Nature Reviews. Microbiology·Namraj GoireDavid M Whiley
May 18, 2019·Health Technology Assessment : HTA·Jonathan Dc RossTessa Lawrence
Jul 12, 2014·Sexually Transmitted Diseases·Bang-yong ZhuJiang-ping Wei
Feb 18, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B Suay-García, M T Pérez-Gracia
Jun 20, 2018·Antibiotics·Beatriz Suay-García, María Teresa Pérez-Gracia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.