PMID: 3770049Aug 1, 1986Paper

In vitro activity of the novel antitumor antibiotic fostriecin (CI-920) in a human tumor cloning assay

European Journal of Cancer & Clinical Oncology
W ScheithauerE F Elslager

Abstract

A human tumor cloning assay was utilized to evaluate the antineoplastic activity of the novel antitumor antibiotic fostriecin (CI-920). Initial screening with 10.0 mcg/ml continuous exposure against a variety of histologic tumor types resulted in 14/51 (27%) in vitro responses (defined as greater than 50% decrease in TCFUs). Further investigation of the compound was performed in 1-hr preincubation experiments. The in vitro response rate at a concentration of 1.0 mcg/ml (which was considered to correspond to a clinically achievable concentration) was 15/43 (35%). Response rates for specific tumor types included: 5/15 in ovarian cancer, 5/12 in breast, and 4/11 in human lung cancer. The impression of significant antitumor activity of the compound at this dose was further substantiated by comparing its in vitro activity with a variety of simultaneously tested standard anticancer agents. In addition, these data indicated the possibility of non-cross resistance of CI-920 to several established cytostatics. CI-920 is a compound with good in vitro activity which should be further developed for clinical trials.

References

Oct 1, 1977·The Journal of Clinical Investigation·A Hamburger, S E Salmon
Jul 29, 1977·Science·A W Hamburger, S E Salmon
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·R LudwigS E Salmon

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Citations

Mar 11, 2006·Archives of Pharmacal Research·Bok Hee KimYongseog Chung
May 12, 2011·Chemical Communications : Chem Comm·Yanping WangGeorge A O'Doherty
Apr 1, 1990·The British Journal of Radiology·K R Rao, H Fritz-Niggli
Sep 25, 2004·Bioorganic & Medicinal Chemistry·Angelo de FatimaRonaldo Aloise Pilli
Mar 10, 1999·British Journal of Cancer·R S de JongE G de Vries
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunanda BasuHal E Broxmeyer
Jul 21, 2010·Chemistry : a European Journal·Yujiro HayashiMitsuru Shoji
May 16, 2017·The Journal of Clinical Investigation·Shirish Shenolikar
Nov 1, 1988·Biochemical Pharmacology·T J BoritzkiD W Fry
Mar 8, 2002·Journal of Medicinal Chemistry·Adam McCluskeyJennette A Sakoff
Dec 29, 2016·Chemical Reviews·Barry M TrostCheyenne S Brindle
Oct 5, 2019·Organic Letters·Dong GaoGeorge A O'Doherty
Nov 3, 2006·Organic Letters·Toshifumi TakeuchiFumio Sugawara
May 24, 2003·Organic Letters·Samir BouzBouz, Janine Cossy
Jul 7, 2001·Organic Letters·J CossyS BouzBouz

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