In vitro activity of tosufloxacin (A-61827; T-3262) against selected genital pathogens.

Antimicrobial Agents and Chemotherapy
J SegretiH A Kessler

Abstract

The in vitro activity of tosufloxacin (A-61827; T-3262) against 15 clinical isolates of Chlamydia trachomatis and 31 recent clinical isolates of Neisseria gonorrhoeae, including 15 spectinomycin-resistant N. gonorrhoeae and 16 penicillinase-producing N. gonorrhoeae, was determined. Tosufloxacin was compared with doxycycline, ciprofloxacin, and temafloxacin against C. trachomatis. Susceptibility testing was performed by using McCoy cell monolayers. The in vitro activity of tosufloxacin against N. gonorrhoeae was compared with that of ciprofloxacin, temafloxacin, doxycycline, ceftriaxone, and spectinomycin by using an agar dilution method. Tosufloxacin was as active as temafloxacin against C. trachomatis (MIC for 90% of strains tested [MIC90], 0.25 microgram/ml; MBC for 90% of strains tested [MBC90], 0.25 microgram/ml) and was almost as active as doxycycline (MIC90, 0.06 microgram/ml; MBC90, 0.125 microgram/ml). Ciprofloxacin, temafloxacin, and tosufloxacin were extremely active against N. gonorrhoeae, including spectinomycin-resistant N. gonorrhoeae and penicillinase-producing N. gonorrhoeae, with MIC90s of 0.004, 0.015, and 0.008 microgram/ml, respectively. Ceftriaxone was slightly less active (MIC90, 0.03 microgram/ml), and do...Continue Reading

References

Jul 1, 1989·Reviews of Infectious Diseases·J D Oriel
Jan 1, 1989·Antimicrobial Agents and Chemotherapy·J SegretiG M Trenholme
Apr 1, 1989·The Journal of Antimicrobial Chemotherapy·A L Barry, R N Jones
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·K FujimakiS Mitsuhashi
May 1, 1988·Antimicrobial Agents and Chemotherapy·A M EspinozaH C Neu
Jan 1, 1988·Antimicrobial Agents and Chemotherapy·P B FernandesD J Hardy

❮ Previous
Next ❯

Citations

Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A R Ronald, R W Peeling
May 1, 1992·Diagnostic Microbiology and Infectious Disease·J SegretiG M Trenholme
Mar 1, 1992·Antimicrobial Agents and Chemotherapy·M R HammerschlagP M Roblin
Nov 18, 2000·Antimicrobial Agents and Chemotherapy·U Dreses-WerringloerL Köhler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Related Papers

Antimicrobial Agents and Chemotherapy
N X ChinH C Neu
The Journal of Antimicrobial Chemotherapy
J M Smith, Z S Hashmi
The Journal of Antimicrobial Chemotherapy
J M AndrewsR Wise
© 2021 Meta ULC. All rights reserved