In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.

Antimicrobial Agents and Chemotherapy
M H CynamonTrudy H Grossman

Abstract

The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.

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Oct 31, 2015·Journal of Medical Microbiology·Isha SoniSidharth Chopra
Jan 17, 2017·Expert Opinion on Investigational Drugs·Matthew E Falagas, Maria Georgiou
Apr 2, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jamie J KisgenLindsey M Childs
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Jun 25, 2021·Future Medicinal Chemistry·Christophe R CantelliPascal Sonnet

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