In vitro activity of trimethoprim in association with sulfimidazole against aerobic gram-negative and gram-positive microorganisms and Clostridia

Mario CastelliI Galatulas


The in vitro activity of a chemotherapeutic agent, sulfimidazole (SIZ), obtained by combining two molecules belonging to groups of extremely different antibacterial drugs, p-aminobenzene sulfonamide and a derivative with a 5-nitroimidazole ring, was studied. In association with trimethoprim, SIZ induces an intense synergistic antibacterial effect on gram-negative and gram-positive aerobic microorganisms and Clostridia. The results show that, in SIZ, the activity of each starting molecule remains unchanged providing that its structure-action relationship is kept intact.


Nov 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica MalagoliMario Castelli
Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·Mario CastelliG Baggio

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