In vitro adsorption of ciprofloxacin on activated charcoal and Talc

American Journal of Therapeutics
E C IbezimO E Orisakwe

Abstract

The in vitro adsorption of ciprofloxacin, a broad-spectrum antimicrobial with actions against a wide variety of microorganisms on activated charcoal (AC) and talc (TC), was investigated at various pH values that simulate the pH of most regions of the gastrointestinal tract. The results of the study indicate that AC and TC adsorbed ciprofloxacin effectively. Adsorption depended on the quantity of the adsorbents used, and for AC adsorption was complete within 2 hours and for TC it was complete within 1 hour with 0.5 g of either of the adsorbents. AC exhibited higher adsorptive capacity for ciprofloxacin than TC. Overall, AC and TC could be used as effective antidotes in poisoning resulting from ciprofloxacin.

Citations

Apr 13, 2005·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·P A ChykaUNKNOWN European Association of Poisons Centres and Clinical Toxicologists
Jan 7, 2016·Colloids and Surfaces. B, Biointerfaces·Zhaohui LiWei-Teh Jiang
Jan 1, 2012·Journal of Environmental Sciences (China)·El-Said Ibrahim El-ShafeyAsmaa Soliman Al-Sumri
Jul 8, 2011·Water Research·S A C CarabineiroJ L Figueiredo
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

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