In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites.

Acta Parasitologica
Laura Fuhrich FabresMarilise Brittes Rott


Several strains of the free-living genus Acanthamoeba can cause granulomatous amoebic encephalitis (GAE), a rare chronic and slowly progressive infection of the central nervous system (CNS), and Acanthamoeba keratitis (AK), a sight-threatening eye infectious disease. AK incidence has increased with the popularization of the contact lens wear and its treatment is currently limited and frequently unsuccessful. As imidazolium salts (IS), cationic imidazole derivatives, have promising antimicrobial potential. The present study evaluated the amoebicidal activity of four IS; 1-n-hexadecyl-3-methylimidazolium methanesulfonate (C16MImMeS), chloride (C16MImCl) and bis (triluoromethylsulfonyl) imide (C16MImNTf2 ), and 1-methyl-3-n-octadecylimidazolium chloride (C18MImCl), against the Acanthamoeba castellanii (ATCC30010) environmental strain and a clinical isolate (genotype T4). Three IS showed being lethal to 100% of the Acanthamoeba trophozoites at the minimum inhibitory concentrations of 125 and 62.5 μg/mL (C16MImMeS), 31.25 and 62.5 μg/mL (C16MImCl), and 125 and 125 μg/mL (C18MImCl) for ATCC30010 and isolate T4, respectively. C16MImNTf2 did not demonstrate amoebicidal activity. All active IS caused the hemolysis of erythrocytes. The c...Continue Reading


Dec 22, 1999·Microbes and Infection·Jerry Y NiederkornJ P McCulley
Apr 15, 2003·Clinical Microbiology Reviews·F Marciano-Cabral, G A Cabral
Feb 28, 2006·Trends in Parasitology·Daniel W Clarke, Jerry Y Niederkorn
Jun 16, 2006·FEMS Microbiology Reviews·Naveed Ahmed Khan
Sep 26, 2006·The Journal of Clinical Investigation·Olga V NikolskaiaDennis J Grab
Apr 13, 2007·FEMS Immunology and Medical Microbiology·Govinda S VisvesvaraFrederick L Schuster
Feb 12, 2009·European Journal of Medicinal Chemistry·Emanuel Hernández-NúñezGabriel Navarrete-Vazquez
Dec 17, 2009·Bioorganic & Medicinal Chemistry Letters·Sanjay V Malhotra, Vineet Kumar
Jun 4, 2010·Journal of Clinical Microbiology·Céline CoulonVincent Thomas
Aug 3, 2010·Bioorganic & Medicinal Chemistry·Carlos Nava-ZuazoGabriel Navarrete-Vazquez
Feb 5, 2013·Bioorganic & Medicinal Chemistry·Yin GaoInka Brockhausen
Feb 26, 2013·Trends in Parasitology·Jacob Lorenzo-MoralesBasilio Valladares
Aug 28, 2013·Chemical Society Reviews·Siti Nurhanna Riduan, Yugen Zhang
May 6, 2014·Journal of Hazardous Materials·Robert BiczakPiotr Rychter
May 27, 2014·Experimental Parasitology·Miray Ustüntürk, Zuhal Zeybek
Oct 7, 2014·The Journal of Eukaryotic Microbiology·Paul A FuerstMonica Crary
Feb 18, 2015·Parasite : Journal De La Société Française De Parasitologie·Jacob Lorenzo-MoralesJulia Walochnik
Apr 25, 2015·International Journal of Antimicrobial Agents·Jack Norman Pendleton, Brendan F Gilmore
Jul 26, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Satya Sree N KolarJan P G Bergmanson
Nov 20, 2015·Parasitology Research·Maritza Omaña-MolinaAdolfo Martinez-Palomo
Mar 19, 2016·Cornea·Nicholas J R Maycock, Rakesh Jayaswal
Sep 8, 2016·Antimicrobial Agents and Chemotherapy·Ruqaiyyah SiddiquiNaveed Ahmed Khan
Sep 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dariana Pimentel Gomes HübnerTiana Tasca
Nov 12, 2016·Survey of Ophthalmology·Linda Christian Carrijo-CarvalhoFabio Ramos de Souza Carvalho
Apr 4, 2017·Journal of Negative Results in Biomedicine·Ruqaiyyah SiddiquiNaveed Ahmed Khan
Jul 1, 2017·Annals of Agricultural and Environmental Medicine : AAEM·Katarzyna Król-Turmińska, Alina Olender
Sep 19, 2017·Experimental Parasitology·Farhat AbjaniRuqaiyyah Siddiqui
Dec 2, 2017·Pest Management Science·Emanuelle GoellnerOnilda Santos da Silva
Jan 6, 2018·Biophysics Reviews·Da WangPatrick Drücker
Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ouldouz GhashghaeiRodolfo Lavilla
Aug 6, 2018·International Immunopharmacology·Raísha Costa MartinsPedro Roosevelt Torres Romão
Apr 26, 2019·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Faaiq HassanAnkur Barua
May 7, 2019·Experimental Parasitology·Ines SifaouiJacob Lorenzo-Morales

Methods Mentioned

infrared spectroscopy
mechanical dissociation

Related Concepts

RAW 264.7 Cells
Cultured Cells
Impacts, Environmental
Intravascular Hemolysis
Homo sapiens

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