In vitro analysis of anionic collagen scaffolds for bone repair

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Patricia L MoreiraSelma Candelária Genari

Abstract

Collagen has been extensively described as a beneficial material in bone tissue engineering due to its biocompatibility, biodegradability, low antigenicity, and high tensile strength. However, collagen scaffolds in their pure form have some drawbacks and improvements in the physical, chemical, and biologic properties of collagen are necessary to overcome those inadequacies. Recently, the selective hydrolysis of carboxyamides of asparagine and glutamine residues of collagen has been employed to increase the number of negative sites and enhance the piezoelectric properties of collagen. Anionic collagen scaffolds were prepared by use of a hydrolysis treatment for either 24 h [bovine pericardium (BP 24)] or 48 h (BP 48). Bovine osteoblasts were cultured on them and on native matrices to understand the cellular interactions responsible for the good osteoconductivity and biocompatibility reported with in vivo tests. Based on the data obtained on cell adhesion, alkaline phosphatase (ALP) and extracellular matrix macromolecule production, and cellular proliferation through histological analysis, we may conclude that the materials tested reveal sufficient biocompatibility level for bone repair. Further, the evidence of some connection b...Continue Reading

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Citations

Oct 5, 2007·Journal of Materials Science. Materials in Medicine·Marcelo Rodrigues CunhaSelma C Genari
Sep 19, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patrícia da Luz MoreiraArnaldo Rodrigues Santos
Jul 4, 2006·Journal of Biomedical Materials Research. Part a·Lenaldo B RochaMarcos A Rossi
Sep 10, 2020·International Journal of Molecular Sciences·Gangadhar LekshmiWanxi Peng
Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang

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