PMID: 8954170Jan 1, 1996Paper

In vitro analysis of cancer prevention by a mycobacterial antigen complex and of cancer-promoted inhibition of immune reactions

Journal of Cancer Research and Clinical Oncology
H Maes, C Cocito

Abstract

The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, they were suppressed in the case of neoplastic growth. In the present work, these in vivo observations were analyzed by in vitro techniques. Activated macrophages played a major role, and cytolytic T lymphocytes a minor role, in A60-promoted cancer cell cytolysis leading to tumor rejection. In vitro, EMT 6 cells weakly inhibited the proliferation of A60-specific B lymphocytes and strongly inhibited the functions of activated macrophages. However, the collapse of both humoral and cellular immune reactions during the course of cancer development was also accompanied by an inhibitory action of EMT 6 cells on the multiplication and functions of A60-specific T lymphocytes. Tumor-dependent repression of macrophage activation was therefore due to both a direct action of tumor cells on macrophages and an indirect one via inhibition of macrophage-activating T cell functions. On the other hand, tumor-induced collapse of the a...Continue Reading

References

Sep 1, 1977·The Journal of Experimental Medicine·J T KungD W Talmage
Jan 1, 1977·Annual Review of Medicine·E M HershG M Mavligit
Jan 1, 1978·Advances in Cancer Research·L Milas, M T Scott
Jan 1, 1978·Advances in Cancer Research·R W Baldwin, M V Pimm
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·J L Svennevig, H Svaar
Jan 1, 1975·Advances in Cancer Research·O Stutman
Jan 1, 1992·Advances in Cancer Research·E Kedar, E Klein
Apr 1, 1992·Clinical and Experimental Immunology·R D HubbardC Cocito
Jan 1, 1992·Annual Review of Immunology·J L Urban, H Schreiber
Jun 1, 1987·Scandinavian Journal of Immunology·C CocitoC Benoit
Apr 1, 1986·Journal of the National Cancer Institute·M R YoungM Newby
Nov 1, 1986·Scandinavian Journal of Immunology·I FabreC Cocito
Jan 1, 1973·Advances in Cancer Research·J H KerseyR A Good
Sep 15, 1973·International Journal of Cancer. Journal International Du Cancer·J H KerseyR A Good
Jul 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Bartholomew
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·C CoetsierC Cocito
Feb 1, 1995·Scandinavian Journal of Immunology·C Cocito, F Vanlinden
Aug 1, 1994·Canadian Journal of Microbiology·P Gilot, M Coene

❮ Previous
Next ❯

Citations

Mar 21, 1998·European Journal of Clinical Investigation·C Cocito, H Maes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.