PMID: 8954170Jan 1, 1996Paper

In vitro analysis of cancer prevention by a mycobacterial antigen complex and of cancer-promoted inhibition of immune reactions

Journal of Cancer Research and Clinical Oncology
H Maes, C Cocito

Abstract

The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, they were suppressed in the case of neoplastic growth. In the present work, these in vivo observations were analyzed by in vitro techniques. Activated macrophages played a major role, and cytolytic T lymphocytes a minor role, in A60-promoted cancer cell cytolysis leading to tumor rejection. In vitro, EMT 6 cells weakly inhibited the proliferation of A60-specific B lymphocytes and strongly inhibited the functions of activated macrophages. However, the collapse of both humoral and cellular immune reactions during the course of cancer development was also accompanied by an inhibitory action of EMT 6 cells on the multiplication and functions of A60-specific T lymphocytes. Tumor-dependent repression of macrophage activation was therefore due to both a direct action of tumor cells on macrophages and an indirect one via inhibition of macrophage-activating T cell functions. On the other hand, tumor-induced collapse of the a...Continue Reading

References

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Citations

Mar 21, 1998·European Journal of Clinical Investigation·C Cocito, H Maes

Related Concepts

A60 antigen, Mycobacterium bovis
Metazoa
Antigens, Bacterial
B-Lymphocytes
Immunologic Tumoricidal Activities
Immunotherapy
Lymphocyte Activation
Macrophage Activation
Mammary Neoplasms, Experimental
Mice, Inbred BALB C

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