In vitro analysis of overall particulate contamination exposure during multidrug IV therapy: impact of infusion sets

Pediatric Blood & Cancer
Maxime PerezPascal Odou

Abstract

Drug incompatibilities, recognizable through precipitate, may have clinical consequences for patients, especially during multidrug IV therapies, where vancomycin and piperacillin are present. Drug concentration and infusion set influence the overall particulate contamination of pediatric infusion protocols. The use of multi-lumen infusion sets could prevent such incompatibilities. Our goal was to define and assess a new way to infuse these drugs during leukemia treatment in children. This in vitro study focused on a pediatric multidrug protocol for patients diagnosed with lymphoblastic leukemia and receiving allogeneic transplantation. Different vancomycin concentrations were tested to infuse incompatible drugs simultaneously without any particle formation (optimized multidrug protocol). A dynamic particle count test was used over 24 hr to evaluate the overall particulate contamination of our standard and optimized multidrug protocols, using both a standard and a multi-lumen infusion set. No visible particles were detected on a decreased vancomycin concentration compared to the standard dose. For the optimized multidrug protocol, the use of a multi-lumen infusion set reduced overall particulate contamination by 68%, compared to...Continue Reading

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Citations

May 22, 2020·The Journal of Pharmacy and Pharmacology·Ayat AbdelkaderMahmoud Elsabahy
Oct 23, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Patricia WorthingtonUNKNOWN ASPEN PN Safety Committee
Mar 27, 2021·European Journal of Clinical Pharmacology·Laura NégrierBertrand Décaudin
Apr 24, 2018·Anaesthesia Critical Care & Pain Medicine·Malik BenlabedBertrand Décaudin

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