In vitro analysis of the anthelmintic activity of forage chicory (Cichorium intybus L.) sesquiterpene lactones against a predominantly Haemonchus contortus egg population

Veterinary Parasitology
Joyce G FosterKenneth E Turner

Abstract

The anthelmintic activity of chicory (Cichorium intybus L.) herbage has been attributed to sesquiterpene lactones. Chicory leaves contain significant amounts of lactucin (LAC), 8-deoxylactucin (DOL), and lactucopicrin (LPIC), but the proportions of these three sesquiterpene lactones vary among forage chicory cultivars. To determine whether the individual compounds differ in anthelmintic activity, we prepared sesquiterpene lactone-enriched extracts from leaves of two forage chicory cultivars, 'Grasslands Puna' (Puna) and 'Forage Feast', and tested their effects on the hatching of a predominantly Haemonchus contortus egg population. The dominant constituents in the Puna and Forage Feast extracts were DOL and LAC, respectively; LPIC concentrations in the two extracts were similar. Extracts from both cultivars inhibited egg hatching at all concentrations tested (P<0.001), but there were significant differences in egg responses to the two extracts (P<0.001). With Puna, egg hatching decreased sharply in a linear fashion when the combined LAC, DOL, and LPIC concentrations ranged from 0 to 5.0mg/ml. A biphasic effect on egg hatching occurred with the Forage Feast extract. The fraction of eggs that hatched decreased gradually to 65% as ...Continue Reading

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Citations

Jan 1, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Renée A StreetGerhard Prinsloo
Jul 24, 2013·Critical Reviews in Toxicology·M Helena R AmorimMargarida M S M Bastos
Mar 13, 2018·Parasite : Journal De La Société Française De Parasitologie·Sujogya Kumar Panda, Walter Luyten
May 5, 2017·The Onderstepoort Journal of Veterinary Research·Erika A Van ZylCathy Stevens
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Farooq KhanHidayat Hussain
Jan 8, 2017·BMC Complementary and Alternative Medicine·Mohammad ShoaibMohammad Naveed Umer
May 21, 2019·Parasitology·Francianne Oliveira SantosMariana Borges Botura
Feb 23, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Angela H ValenteAndrew R Williams

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.