PMID: 698922Nov 1, 1978Paper

In vitro analysis of the response of multicellular tumor spheroids exposed to chemotherapeutic agents in vitro or in vivo

Cancer Research
J M YuhasJ G Harman

Abstract

Multicellular tumor spheroids (MTS) have been exposed to chemotherapeutic agents in vitro (nitrogen mustard) or in vivo (cyclophosphamide) and analyzed in vitro in terms of altered growth patterns. Whether the MTS were exposed in vitro or in vivo, the major effect of the drugs was to induce a dose-dependent lag period before the normal MTS growth rate resumed. Exposure of MTS in the peritoneal cavity to i.v. injection cyclophosphamide results in patterns similar to the in vitro exposure system, except that a host anti-MTS reaction was detected. In combination, these two methods allow the study of the responses of these complex tumor forms to chemotherapy.

Related Concepts

Antineoplastic Agents
Cell Division Phases
Cyclophosphamide, (S)-Isomer
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Nitromin brand of mechlorethamine oxide
Mice, Inbred BALB C
Neoplasms, Experimental

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