In Vitro and Ex Vivo Models - The Tumor Microenvironment in a Flask

Advances in Experimental Medicine and Biology
Catarina PintoCatarina Brito

Abstract

Experimental tumor modeling has long supported the discovery of fundamental mechanisms of tumorigenesis and tumor progression, as well as provided platforms for the development of novel therapies. Still, the attrition rates observed today in clinical translation could be, in part, mitigated by more accurate recapitulation of environmental cues in research and preclinical models. The increasing understanding of the decisive role that tumor microenvironmental cues play in the outcome of drug response urges its integration in preclinical tumor models. In this chapter we review recent developments concerning in vitro and ex vivo approaches.

Citations

Jun 4, 2020·Biomolecules·Bon Ham Yip
Aug 23, 2020·Cancers·Roberta LarangaEnrico Lucarelli

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