In vitro and ex vivo selection procedures for identifying potentially therapeutic DNA and RNA molecules.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Soledad MartonAlfredo Berzal-Herranz

Abstract

It was only relatively recently discovered that nucleic acids participate in a variety of biological functions, besides the storage and transmission of genetic information. Quite apart from the nucleotide sequence, it is now clear that the structure of a nucleic acid plays an essential role in its functionality, enabling catalysis and specific binding reactions. In vitro selection and evolution strategies have been extremely useful in the analysis of functional RNA and DNA molecules, helping to expand our knowledge of their functional repertoire and to identify and optimize DNA and RNA molecules with potential therapeutic and diagnostic applications. The great progress made in this field has prompted the development of ex vivo methods for selecting functional nucleic acids in the cellular environment. This review summarizes the most important and most recent applications of in vitro and ex vivo selection strategies aimed at exploring the therapeutic potential of nucleic acids.

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Citations

Nov 8, 2011·Nature Nanotechnology·Andre V PinheiroHao Yan
Nov 10, 2013·PloS One·M Elena MartínVíctor M González
Sep 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alba Fernández-SanlésAlfredo Berzal-Herranz
Aug 27, 2015·Life·Ádám Kun, Eörs Szathmáry
Jan 11, 2013·Journal of Viral Hepatitis·S MartonA Berzal-Herranz
Aug 29, 2013·Reviews in Medical Virology·Cristina Romero-López, Alfredo Berzal-Herranz
Jul 16, 2015·PloS One·Nithya SubramanianSubramanian Krishnakumar
Dec 22, 2016·Pharmaceuticals·Víctor M GonzálezAna García-Sacristán
Apr 23, 2016·PloS One·Soledad MartonJosiane Cardoso
Mar 17, 2017·Pharmaceuticals·Cristina Romero-López, Alfredo Berzal-Herranz
Jan 1, 2011·Pharmaceuticals·Soledad MartonAlfredo Berzal-Herranz
Jan 29, 2020·Biotechnology Progress·Kazem MashayekhiMojtaba Sankian
Sep 10, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Chengzhen XuXiaomin Wu
Mar 16, 2019·Pharmaceuticals·Alfredo Berzal-HerranzSara Ramos-Lorente
Jul 28, 2020·Pharmaceuticals·Alfredo Berzal-Herranz, Cristina Romero-López
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kingshuk PandaDeepti Parashar

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Methods Mentioned

BETA
PCR
in vitro transcription
chemical
transfection
xenograft
SELEX
coronary artery bypass

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