In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O -gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Koichi SaekiMamoru Isemura

Abstract

Green tea has been shown to have beneficial effects on many diseases such as cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea component, epigallocatechin-3-O-gallate (EGCG), has been demonstrated to contribute to these effects through its anti-oxidative and pro-oxidative properties. Furthermore, several lines of evidence have indicated that the binding affinity of EGCG to specific proteins may explain its mechanism of action. This review article aims to reveal how EGCG-protein interactions can explain the mechanism by which green tea/EGCG can exhibit health beneficial effects. We conducted a literature search, using mainly the PubMed database. The results showed that several methods such as dot assays, affinity gel chromatography, surface plasmon resonance, computational docking analyses, and X-ray crystallography have been used for this purpose. These studies have provided evidence to show how EGCG can fit or occupy the position in or near functional sites and induce a conformational change, including a quaternary conformational change in some cases. Active site blocking, steric hindrance by binding of EGCG near an active site or induced conformational change appeared to cause inhibi...Continue Reading

References

Jun 5, 1997·Nature·J JankunE Skrzypczak-Jankun
Oct 27, 1997·Bioscience, Biotechnology, and Biochemistry·M SazukaM Isemura
Jul 2, 1998·Bioscience, Biotechnology, and Biochemistry·M SazukaS Isemura
Jul 24, 1998·Mutation Research·H FujikiK Nakachi
May 4, 2000·Journal of Agricultural and Food Chemistry·M Maeda-YamamotoM Isemura
Aug 2, 2001·Biochemical and Biophysical Research Communications·S HayakawaM Isemura
Mar 17, 2004·Nature Structural & Molecular Biology·Hirofumi TachibanaKoji Yamada
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul A TownsendAnastasis Stephanou
Feb 17, 2005·The Journal of Biological Chemistry·Svetlana ErmakovaZigang Dong
Feb 14, 2006·Current Molecular Medicine·Jianze Li, Amy S Lee
Apr 14, 2006·Current Medicinal Chemistry·Wei-Xi Tian
Mar 21, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ming LiZigang Dong
May 31, 2008·Nature Structural & Molecular Biology·Dagmar E EhrnhoeferErich E Wanker
Jan 8, 2010·International Journal of Molecular Sciences·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Oct 28, 2010·British Journal of Pharmacology·Naoto TadanoToshiyuki Sasaguri
Jan 14, 2011·Journal of Nutritional Science and Vitaminology·Kanako MinodaTsutomu Nakayama
Feb 9, 2011·Biochemical and Biophysical Research Communications·Glenn S Van AllerLusong Luo
Feb 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shulin QinTodd A Reinhart
Mar 2, 2011·Journal of Lipid Research·Massimiliano CuccioloniMauro Angeletti
Mar 23, 2011·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hirofumi Tachibana
Apr 22, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yukihiko Hara
Jul 14, 2011·Cancer Prevention Research·Darya V UrusovaZigang Dong
Sep 17, 2011·Journal of Chemical Information and Modeling·Roman A Laskowski, Mark B Swindells
Dec 1, 2011·Appetite·Andrew ScholeyCon Stough
Jan 31, 2012·The Journal of Physical Chemistry. B·Yassmine ChebaroPhilippe Derreumaux
Mar 28, 2012·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yasuo SuzukiMamoru Isemura
Jun 6, 2012·PloS One·Yoshinori FujimuraHirofumi Tachibana

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Citations

Sep 27, 2019·Current Developments in Nutrition·Rattiyaporn Kanlaya, Visith Thongboonkerd
Aug 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shogo NakanoSohei Ito
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sung-Yen LinChung-Hwan Chen
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wang WangLinfang Du
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mamoru Isemura
Aug 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jie ShengYao Xu
Oct 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sumio HayakawaMamoru Isemura
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomokazu OhishiMamoru Isemura
Sep 13, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mingxi LiLiya Li
Jan 23, 2021·International Journal of Molecular Sciences·Kenneth R OlsonKarl D Straub
Sep 26, 2020·Clinical Oral Investigations·Melissa Thiemi KatoMarília Afonso Rabelo Buzalaf
Mar 29, 2021·Food Research International·A RashidinejadS M Jafari
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liqing ZangNorihiro Nishimura
Oct 5, 2021·Critical Reviews in Food Science and Nutrition·Ramkumar SamynathanJosé M Lorenzo

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Methods Mentioned

BETA
quartz crystal microbalance
pull-down
xenograft
NMR
MDA
X-ray
acylation
deamination

Software Mentioned

Autodock
Energetics Maestro
MDA
Grid

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