In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

The Journal of Infectious Diseases
Julie DyallLisa E Hensley

Abstract

At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testing, we confirmed anti-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect guinea pigs from a lethal dose of Ebola virus.

References

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Apr 9, 2014·The Journal of Antimicrobial Chemotherapy·Gerrit GehringThomas von Hahn
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Aug 2, 2017·Current Therapeutic Research, Clinical and Experimental·Hussein SweitiStefan K Lhachimi

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Citations

Aug 23, 2019·Medicinal Research Reviews·Catherine H Schein
Mar 22, 2019·Viruses·Cristiano SalataGiorgio Palù
Dec 29, 2020·Frontiers in Pharmacology·José Miguel Vela
Jul 20, 2020·Antiviral Research·Thomas R LaneSean Ekins
Mar 6, 2021·Indian Journal of Pharmacology·Snehal LonareChandra Kr Das
Sep 14, 2021·Journal of Chemical Information and Modeling·Thomas R Lane, Sean Ekins

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