PMID: 25764632Mar 15, 2015Paper

In vitro and in vivo activity of tebipenem against ESBL-producing E. coli

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Visanu ThamlikitkulSurapee Tiengrim

Abstract

To determine in vitro and in vivo activity of tebipenem against ESBL-producing E. coli. Minimum inhibitory concentration (MIC) of tebipenem against 100 clinical isolates of ESBL-producing E. coli was performed by broth micro-dilution technique. Blood and urine samples from 10 healthy male subjects before and after receiving 300 mg of tebipenem pivoxil 3 times a day for 2 consecutive days were determined for inhibitory and bactericidal titers against a clinical urinary isolate of ESBL-producing E. coli by disk diffusion method and broth micro- dilution method. MIC50 and MC90 of tebipenem against ESBL-producing E. coli were both 0.06 mg/L with MIC range from ≤ 0.06 to 0.25 mg/L. The inhibition zones were observed around the disks inoculated with serum samples and urine samples collected from all study subjects after receiving tebipenem pivoxil for at least 1 hour and 5 hours, respectively. The inhibitory titer of 1:160 and bactericidal titer of 1:160 of serum samples were observed for at least one hour after ingestion of tebipenem pivoxil. Inhibitory titer of 1:640 and bactericidal titer of 1:640 of urine samples were observed after at least 14 hours after ingestion of tebipenem pivoxil. No subjects experienced side effects relat...Continue Reading

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