Abstract
We investigated the effects of the brominated phenolic and phenol compounds, some of which are brominated flame retardants, on the binding of (125)I-3,3',5-L-triiodothyronine ((125)I-T(3)) to purified Xenopus laevis transthyretin (xTTR) and to the ligand-binding domain of X. laevis thyroid hormone receptor beta (xTR LBD), on the induction of a T(3)-responsive reporter gene in a recombinant X. laevis cell line (XL58-TRE-Luc) and on T(3)-induced or spontaneous metamorphosis in X. laevis tadpoles. Of the brominated phenolic and phenol compounds tested, 3,3',5-tribromobisphenol A and 3,3'-dibromobisphenol A were the most potent competitors of (125)I-T(3) binding to xTTR and the xTR LBD, respectively. Structures with a bromine in either ortho positions with respect to the hydroxy group competed more efficiently with T(3) binding to xTTR and the xTR LBD. 3,3',5-Tribromobisphenol A and 3,3',5,5'-tetrabromobisphenol A, at 0.1-1.0 microM, exerted both T(3) agonist and antagonist activities in the T(3)-responsive reporter gene assay. Sera obtained from fetal bovine and bullfrog tadpoles weakened the T(3) agonist and antagonist activities of 3,3',5-tribromobisphenol A, but not the T(3) antagonist activity of o-t-butylphenol, for which xTT...Continue Reading
References
Jul 1, 1979·Endocrinology·H H SamuelsJ Casanova
May 7, 1976·Analytical Biochemistry·M M Bradford
Aug 1, 1987·Endocrinology·J J ByrneE A Hanson
Jun 1, 1985·General and Comparative Endocrinology·M LarssonA Carlström
Oct 1, 1984·Bulletin of Environmental Contamination and Toxicology·I WatanabeR Tatsukawa
Jun 1, 1980·Molecular and Cellular Endocrinology·A M LennonJ Nunez
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
May 1, 1993·Endocrinology·K YamauchiR Horiuchi
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Feb 14, 1998·Toxicology and Industrial Health·A BrouwerT J Visser
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
Jan 23, 1999·European Journal of Biochemistry·L ChangG Schreiber
Mar 25, 1999·Environmental Health Perspectives·A O CheekJ A McLachlan
Jun 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·I A MeertsA Brouwer
Oct 6, 2000·General and Comparative Endocrinology·K YamauchiS J Richardson
Aug 22, 2001·Chemosphere·H FukazawaY Terao
May 10, 2002·Chemosphere·Kristina JakobssonAke Bergman
Jun 11, 2002·Biochemical and Biophysical Research Communications·Shigeyuki KitamuraNariaki Fujimoto
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Kenji MoriyamaKazuwa Nakao
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Kiyoshi YamauchiAkinori Ishihara
Feb 13, 2003·Molecular and Cellular Endocrinology·Akinori IshiharaKiyoshi Yamauchi
Feb 27, 2003·Marine Pollution Bulletin·In MonirithShinsuke Tanabe
Mar 22, 2003·Toxicology and Applied Pharmacology·Kiyoshi YamauchiYoshiyasu Terao
Dec 31, 2003·Environmental Health Perspectives·Linda S Birnbaum, Daniele F Staskal
Feb 27, 2004·The Journal of Biological Chemistry·Wataru MiyazakiNoriyuki Koibuchi
Apr 6, 2004·Environmental Health Perspectives·Kelly J GaugerR Thomas Zoeller
Jun 4, 2004·Environmental Health Perspectives·Marte BraathenBjørn Munro Jenssen
Dec 14, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yumiko Kudo, Kiyoshi Yamauchi
Jan 28, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Harvey WongBrian Gemzik
Feb 1, 2005·Life Sciences·Shigeyuki KitamuraAkihiko Kashiwagi
May 17, 2005·Toxicology and Applied Pharmacology·C A MeachamT J Shafer
Jul 23, 2005·Molecular Endocrinology·Michelle M Tabb, Bruce Blumberg
Aug 17, 2005·General and Comparative Endocrinology·Shin-Ichiro SugiyamaKiyoshi Yamauchi
Nov 3, 2005·Environmental Health Perspectives·Nathalie TurqueBarbara A Demeneix
Nov 18, 2005·Environmental Research·Oana JagnytschWerner Kloas
Jul 1, 1997·Talanta·M IshiyamaK Ueno
Jan 1, 1946·The Anatomical Record·A C TAYLOR, J J KOLLROS
Nov 1, 1998·Environmental Toxicology and Pharmacology·H W VallackR D Taalman
Citations
Sep 10, 2013·Environmental Science & Technology·Zhanlan FanMin Yang
Apr 7, 2012·Journal of Toxicologic Pathology·Kaori Miyata, Keiko Ose
Jan 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Syunsuke OtsukaKiyoshi Yamauchi
Mar 20, 2010·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Corey Edwards
Jul 6, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T DebenestC Blaise
Nov 17, 2009·Biochemical Pharmacology·Mary-Line JuganJean-Paul Blondeau
Mar 5, 2008·International Journal of Andrology·P O Darnerud
Nov 1, 2012·Journal of Applied Toxicology : JAT·Tomohiro OkaTaisen Iguchi
Aug 11, 2015·Journal of Environmental Sciences (China)·Yinfeng ZhangJianzhong Li
Apr 12, 2015·General and Comparative Endocrinology·Shunsuke SuzukiKiyoshi Yamauchi
Nov 30, 2012·Critical Reviews in Toxicology·S ScholzM R Embry
May 23, 2015·Environmental Science & Technology·Yuyin ZhouJianying Hu
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Dec 29, 2009·General and Comparative Endocrinology·Farhana Babli Rahman, Kiyoshi Yamauchi
Feb 7, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erin M KollitzPatrick Lee Ferguson
Jan 25, 2007·Reviews on Environmental Health·Kiyoshi Yamauchi, Akinori Ishihara
Sep 21, 2017·Frontiers in Veterinary Science·Szandra KlátyikAndrás Székács
Jun 16, 2012·Journal of Environmental Monitoring : JEM·Mee SongJae-Chun Ryu
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
May 29, 2018·Chemosphere·Jamie M Pahigian, Yuegang Zuo
May 16, 2018·Environmental Science & Technology·Liping LuShulin Zhuang
Dec 14, 2021·The Science of the Total Environment·Jaromir MichałowiczBożena Bukowska