In vitro and in vivo analysis of the thyroid system-disrupting activities of brominated phenolic and phenol compounds in Xenopus laevis

Toxicological Sciences : an Official Journal of the Society of Toxicology
Yumiko KudoYoshiyasu Terao

Abstract

We investigated the effects of the brominated phenolic and phenol compounds, some of which are brominated flame retardants, on the binding of (125)I-3,3',5-L-triiodothyronine ((125)I-T(3)) to purified Xenopus laevis transthyretin (xTTR) and to the ligand-binding domain of X. laevis thyroid hormone receptor beta (xTR LBD), on the induction of a T(3)-responsive reporter gene in a recombinant X. laevis cell line (XL58-TRE-Luc) and on T(3)-induced or spontaneous metamorphosis in X. laevis tadpoles. Of the brominated phenolic and phenol compounds tested, 3,3',5-tribromobisphenol A and 3,3'-dibromobisphenol A were the most potent competitors of (125)I-T(3) binding to xTTR and the xTR LBD, respectively. Structures with a bromine in either ortho positions with respect to the hydroxy group competed more efficiently with T(3) binding to xTTR and the xTR LBD. 3,3',5-Tribromobisphenol A and 3,3',5,5'-tetrabromobisphenol A, at 0.1-1.0 microM, exerted both T(3) agonist and antagonist activities in the T(3)-responsive reporter gene assay. Sera obtained from fetal bovine and bullfrog tadpoles weakened the T(3) agonist and antagonist activities of 3,3',5-tribromobisphenol A, but not the T(3) antagonist activity of o-t-butylphenol, for which xTT...Continue Reading

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Citations

Apr 7, 2012·Journal of Toxicologic Pathology·Kaori Miyata, Keiko Ose
Jan 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Syunsuke OtsukaKiyoshi Yamauchi
Jul 6, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T DebenestC Blaise
Nov 17, 2009·Biochemical Pharmacology·Mary-Line JuganJean-Paul Blondeau
Mar 5, 2008·International Journal of Andrology·P O Darnerud
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Dec 29, 2009·General and Comparative Endocrinology·Farhana Babli Rahman, Kiyoshi Yamauchi
Feb 7, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erin M KollitzPatrick Lee Ferguson
Jun 16, 2012·Journal of Environmental Monitoring : JEM·Mee SongJae-Chun Ryu
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
Dec 14, 2021·The Science of the Total Environment·Jaromir MichałowiczBożena Bukowska

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