Abstract
The effects of various extracts from oriental medicinal herbs on mast cell-mediated allergic reactions have been investigated. Among the extracts, Arecae semen was the most potent inhibitor of antigen-induced degranulation in RBL-2H3 mast cells. A. semen inhibited DNP-BSA- and compound 48/80-induced degranulation in RBL-2H3 mast cells with IC(50) values of approximately 53 and 52 microg mL(-1), respectively, and inhibited compound 48/80-induced systemic anaphylaxis by 46% at 300 mg kg(-1) in mice. A. semen also inhibited the expression of TNF-alpha and the activation of mitogen activated protein kinase, ERK1/2, which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of the activating phosphorylation of ERK1/2. These results suggest that A. semen may be useful for the treatment of various immediate and delayed allergic diseases.
References
Dec 1, 1990·Immunology Today·J R GordonS J Galli
Sep 1, 1990·Trends in Pharmacological Sciences·M MousliY Landry
Aug 15, 1970·Nature·U K Laemmli
May 5, 1995·The Journal of Biological Chemistry·N HirasawaJ P Kinet
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Jul 5, 1996·The Journal of Biological Chemistry·B Jabril-CuenodJ P Kinet
May 16, 1997·The Journal of Biological Chemistry·C ZhangM A Beaven
Dec 20, 1999·Journal of Agricultural and Food Chemistry·M SanoM Maeda-Yamamoto
Dec 10, 1999·Nature·H Turner, J P Kinet
May 24, 2000·Cellular Signalling·A AlfonsoL M Botana
Jan 4, 2001·The New England Journal of Medicine·A B Kay
Jan 11, 2001·The New England Journal of Medicine·A B Kay
Feb 19, 2002·Journal of Ethnopharmacology·Jin Mu YiHyung Min Kim
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Yoshinori FujimuraKoji Yamada
May 14, 2003·The Journal of Allergy and Clinical Immunology·Axel LorentzStephan C Bischoff
Sep 10, 2003·Journal of Ethnopharmacology·Seung-Heon HongHyung-Min Kim
Citations
Jul 5, 2011·Analytical and Bioanalytical Chemistry·Junko KoyamaAtsuko Takeuchi
Jul 3, 2013·BMC Complementary and Alternative Medicine·Chia-Chi WangTong-Rong Jan
Feb 12, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-H LeeW-S Choi
Feb 15, 2015·Journal of Ethnopharmacology·Wei PengChun-Jie Wu
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Jun Ho LeeWahn Soo Choi
Nov 28, 2007·Experimental Biology and Medicine·Beong Ou LimWahn Soo Choi
Jan 1, 2012·Biomolecules & Therapeutics·Jong-Woo ParkJeung-Whan Han
Jul 22, 2008·Experimental Biology and Medicine·Jun Ho LeeWahn Soo Choi
Mar 31, 2007·Toxicology and Applied Pharmacology·Jun Ho LeeWahn Soo Choi
May 5, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chia-Chi WangTong-Rong Jan