In-vitro and in-vivo anti-allergic actions of Arecae semen

The Journal of Pharmacy and Pharmacology
Jun Ho LeeWahn Soo Choi

Abstract

The effects of various extracts from oriental medicinal herbs on mast cell-mediated allergic reactions have been investigated. Among the extracts, Arecae semen was the most potent inhibitor of antigen-induced degranulation in RBL-2H3 mast cells. A. semen inhibited DNP-BSA- and compound 48/80-induced degranulation in RBL-2H3 mast cells with IC(50) values of approximately 53 and 52 microg mL(-1), respectively, and inhibited compound 48/80-induced systemic anaphylaxis by 46% at 300 mg kg(-1) in mice. A. semen also inhibited the expression of TNF-alpha and the activation of mitogen activated protein kinase, ERK1/2, which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of the activating phosphorylation of ERK1/2. These results suggest that A. semen may be useful for the treatment of various immediate and delayed allergic diseases.

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Citations

Jul 3, 2013·BMC Complementary and Alternative Medicine·Chia-Chi WangTong-Rong Jan
Feb 12, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-H LeeW-S Choi
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Jun Ho LeeWahn Soo Choi
Nov 28, 2007·Experimental Biology and Medicine·Beong Ou LimWahn Soo Choi
Jan 1, 2012·Biomolecules & Therapeutics·Jong-Woo ParkJeung-Whan Han
Jul 22, 2008·Experimental Biology and Medicine·Jun Ho LeeWahn Soo Choi
Mar 31, 2007·Toxicology and Applied Pharmacology·Jun Ho LeeWahn Soo Choi
May 5, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chia-Chi WangTong-Rong Jan

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