In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells

Nanomedicine : Nanotechnology, Biology, and Medicine
Hongdi WangQiuling Xie

Abstract

Nanotechnology associated with a crystal engineering approach was proposed for improving the solubility and efficacy of hydrophobic drugs in this study. 10-hydroxycamptothecin polymorphic nanoparticle dispersions (HCPT-PNDs) were prepared using the supercritical anti-solvent technique coupled with the high-pressure homogenization method. Shape- and polymorph-dependent tumor suppression was observed in both in vitro and in vivo models, where needle-shaped HCPT-PND exhibited dramatic improvement of antitumor efficacy. A benefit of controllable size and a large surface-to-volume ratio of needle-shaped nanoparticles is the improvement of dissolution properties, which facilitates enhancing pharmacokinetic and pharmaco-dynamic properties. The needle-shaped HCPT-PND, which with longer blood retention time and more effective cellular uptake, makes it possible to accumulate drug in tumor tissues and exhibit higher cytotoxicity. No severe systemic toxicity was observed due to sustained-dissolution and the low dose of drug in normal tissues. The results suggest that the needle-shaped HCPT-PND is an interesting nano-formulation of HCPT. Nanotechnology has enabled the production of novel therapeutics drugs against cancer. Here, the authors ...Continue Reading

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Citations

Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng YangYu-Juan Wang
Aug 30, 2019·Chemical Society Reviews·Lijiao YangXiaoyuan Chen
Oct 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sena KaraosmanogluXianfeng Chen
Feb 18, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yang LiXiaolong Liu
Aug 24, 2021·Journal of Toxicology·Chukwuebuka EgbunaChinwe Gloria Ibeabuchi
May 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tianen WangYa Sun

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