In vitro and in vivo antibacterial activities of S-1090, a new oral cephalosporin.

Antimicrobial Agents and Chemotherapy
M TsujiK Yamaguchi

Abstract

S-1090, a new oral cephalosporin, was active against selected gram-negative bacteria and methicillin-susceptible clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus warneri, against which it had excellent activity. S-1090 was the most active compound against Streptococcus pyogenes and Streptococcus agalactiae among the agents compared. The in vivo efficacy of S-1090 against systemic and urinary and respiratory tract infections caused by gram-positive and -negative bacteria was superior to that expected from the in vitro and in vivo activities of the agents against which it was compared.

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Citations

Oct 23, 2009·Journal of Clinical Microbiology·Masayuki OhtsukaKeiichi Hiramatsu
Nov 4, 2000·Expert Opinion on Investigational Drugs·M Cazzola
Nov 17, 2009·Infectious Disease Clinics of North America·Jose A BazanKenneth M Kaye
Mar 3, 2009·Diagnostic Microbiology and Infectious Disease·Scott A Van WartSujata M Bhavnani
May 21, 2013·International Journal of Antimicrobial Agents·Masanori HaradaKingo Chida
Jan 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seigo HidakaTakayuki Noguchi
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·W J WeissR T Testa
Dec 15, 2020·International Journal of Antimicrobial Agents·Nevio Cimolai
Feb 4, 1998·Antimicrobial Agents and Chemotherapy·M TsujiK Yamaguchi
Jan 1, 1996·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Mitsuyoshi NakashimaHiromichi Imoto

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