PMID: 9420050Jan 7, 1998Paper

In vitro and in vivo antibacterial activities of GV129606, a new broad-spectrum trinem

Antimicrobial Agents and Chemotherapy
E Di ModugnoJ Lowther

Abstract

GV129606 is a new parenteral trinem antibiotic belonging to the beta-lactam class. It combines broad-spectrum activity (against gram-negative and -positive bacteria, aerobes and anaerobes), with high potency and resistance to beta-lactamases. Comparative in vitro and in vivo antibacterial activities were determined for GV129606 against more than 400 recent clinical isolates (aerobes, including beta-lactamase producers, and anaerobes), using representative antibacterial agents (meropenem, piperacillin, ceftazidime, cefpirome, ciprofloxacin, and gentamicin for aerobes and metronidazole, cefoxitin, piperacillin, and clindamycin for anaerobes). Against methicillin-susceptible staphylococci and streptococci, GV129606 and meropenem were the most active of the drugs tested. GV129606 showed an MIC for 90% of strains tested (MIC90) ranging from < or =0.015 to 0.06 microg/ml against methicillin-susceptible staphylococci and Streptococcus sanguis, Streptococcus pyogenes, and Streptococcus agalactiae. Against penicillin-susceptible and -resistant Streptococcus pneumoniae isolates, GV129606, meropenem, and cefpirome showed MIC90s of < or =0.015 and 1 microg/ml, respectively. Meropenem was the most active compound against members of the fami...Continue Reading

References

Aug 21, 1992·Science·H C Neu
May 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C C Sanders
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K BushA A Medeiros
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·E Di ModugnoL Xerri
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·M N Swartz
Mar 1, 1993·Antimicrobial Agents and Chemotherapy·L L Silver, K A Bostian

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Citations

Apr 2, 2002·Expert Opinion on Investigational Drugs·Giovanni BonfiglioGiuseppe Nicoletti
Feb 15, 2001·Expert Opinion on Investigational Drugs·A Bryskier

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