In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic.

Antimicrobial Agents and Chemotherapy
M TaiS Mitsuhashi

Abstract

The activities of T-1982 (sodium 7 beta-[(2R, 3S)-2-(4-ethyl-2, 3-dioxo-1-piperazine-carboxamido)-3-hydroxybutanamido]-7 alpha-methoxy-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylate) against various gram-positive and gram-negative bacteria were compare with those of cefmetazole, cefoxitin, cefazolin, and cefoperazone. T-1982 was active against both gram-positive and gram-negative bacteria, including genera resistant to the other cephalosporins. T-1982 exhibited greater activity than did cefmetazole, cefoxitin, cefazolin, or cefoperazone against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Serratia marcescens and was also highly active against Bacteroides fragilis. T-1982 was as stable to various beta-lactamases as were cefmetazole and cefoxitin. The therapeutic activities of T-1982 in mice experimentally infected with various gram-negative bacteria were superior to those of cefmetazole, cefoxitin, cefazolin, and cefoperazone.

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Citations

Apr 1, 1985·European Journal of Clinical Microbiology·A L BarryC Thornsberry
Sep 1, 1989·Diagnostic Microbiology and Infectious Disease·R N Jones
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Mar 1, 1993·Antimicrobial Agents and Chemotherapy·Y FukuokaH Narita
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·E J Goldstein, D M Citron

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