PMID: 6398120Apr 1, 1984Paper

In vitro and in vivo antifungal activity of the combination methylpartricin-5-fluorocytosine

Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
V StrippoliN Simonetti

Abstract

In vitro studies on the antifungal activity exerted by the combinations SPA-S-222 (a hydrosoluble derivative of the polyene antibiotic methylpartricin) and 5-fluorocytosine evidence a favourable interaction against the formation of germ-tube in Candida albicans; against Cryptococcus neoformans and 5FC induced-resistant strains of Candida albicans. In the experimental infections with Candida albicans and Cryptococcus neoformans a significantly favourable interaction was exerted by polyene-5FC combinations.

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