In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study

Journal of Agricultural and Food Chemistry
Gitte S JensenAlexander G Schauss

Abstract

This study investigated the in vitro and in vivo antioxidant and anti-inflammatory properties of a juice blend (JB), MonaVie Active, containing a mixture of fruits and berries with known antioxidant activity, including acai, a palm fruit, as the predominant ingredient. The phytochemical antioxidants in the JB are primarily in the form of anthocyanins, predominantly cyanidin 3-rutoside, cyanidin 3-diglycoside, and cyanidin 3-glucoside. The cell-based antioxidant protection of erythrocytes (CAP-e) assay demonstrated that antioxidants in the JB penetrated and protected cells from oxidative damage ( p < 0.001), whereas polymorphonuclear cells showed reduced formation of reactive oxygen species ( p < 0.003) and reduced migration toward three different pro-inflammatory chemoattractants: fmlp ( p < 0.001), leukotriene B4 ( p < 0.05), and IL-8 ( p < 0.03). A randomized, double-blinded, placebo-controlled, crossover trial with 12 healthy subjects examined the JB's antioxidant activity in vivo. Blood samples at baseline, 1 h, and 2 h following consumption of the JB or placebo were tested for antioxidant capacity using several antioxidant assays and the TBARS assay, a measure of lipid peroxidation. A within subject comparison showed an in...Continue Reading

References

Feb 5, 2003·The American Journal of Medicine·Penny M Kris-EthertonTerry D Etherton
Jun 10, 2004·Journal of Agricultural and Food Chemistry·Xianli WuRonald L Prior
Oct 7, 2004·European Journal of Pharmacology·Jean-Claude StocletValérie B Schini-Kerth
May 12, 2005·Journal of Agricultural and Food Chemistry·Ronald L PriorKaren Schaich
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 26, 2006·Journal of Agricultural and Food Chemistry·Alexander G SchaussJames P Kababick
Oct 26, 2006·Journal of Agricultural and Food Chemistry·Alexander G SchaussEdward Shanbrom
Jan 4, 2007·The Journal of Pathology·A TermanU T Brunk
May 31, 2007·Journal of the American College of Nutrition·Ronald L PriorRichard A Cook
Jun 15, 2007·The British Journal of Nutrition·Kyu-Ho HanMichihiro Fukushima
Jul 3, 2007·Experimental Gerontology·Anis LarbiGraham Pawelec
Jul 10, 2007·Journal of Physiology and Biochemistry·J A Martínez
Jun 24, 2008·The American Journal of Cardiology·Steven R Steinhubl

❮ Previous
Next ❯

Citations

Mar 19, 2009·Cancer Chemotherapy and Pharmacology·Sarah ThomassetAndreas J Gescher
Mar 7, 2012·Plant Foods for Human Nutrition·Samuele RinelliAlberto Battezzati
Sep 11, 2012·Plant Foods for Human Nutrition·Mariana F FragosoLuis F Barbisan
Oct 20, 2010·The British Journal of Nutrition·Javier González-GallegoMaría J Tuñón
Oct 20, 2010·The British Journal of Nutrition·Gary Williamson, Michael N Clifford
Nov 16, 2011·Journal of Agricultural and Food Chemistry·Lydia KaumeLatha Devareddy
Apr 4, 2012·Journal of Agricultural and Food Chemistry·Xianli Wu, Alexander G Schauss
May 8, 2013·Journal of Agricultural and Food Chemistry·Sema Demirci ÇekiçReşat Apak
Oct 3, 2012·Antioxidants & Redox Signaling·Ignazio BarbagalloGiovanni Li Volti
Feb 23, 2010·Journal of Medicinal Food·Maria Elisa SchreckingerElvira Gonzalez de Mejia
Apr 10, 2013·Journal of Medicinal Food·Jin Xu, Biljana Mojsoska
Nov 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Min Ju Kim, Se-Young Choung
May 4, 2010·BMC Complementary and Alternative Medicine·Stephen P MyersCarol Morris
Aug 21, 2009·The Journal of Nutrition·Tinna TraustadóttirS Mitchell Harman
Dec 18, 2013·Journal of Ethnopharmacology·Rosa Virginia García-RodríguezJesús Samuel Cruz-Sánchez
Mar 31, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·V KapadiaC R Rosenfeld
Apr 14, 2010·Nutrition Reviews·Arpita BasuTimothy J Lyons
Jun 13, 2015·Journal of the American Pharmacists Association : JAPhA·Cindy Leslie A RobersonNancy Elsharkawy
Jan 21, 2016·Food Science & Nutrition·Ehigbai I OikehKelly Oriakhi
Dec 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Roberto Soares de MouraSamuel Santos Valenca
Mar 16, 2012·Journal of Food Science·Federica Cheli, Antonella Baldi
May 23, 2012·Journal of Dietary Supplements·Catherine UlbrichtRegina Windsor
Jul 4, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jacqueline Carvalho-PeixotoPaulo de Tarso Veras Farinatti
Feb 28, 2015·Food Chemistry·Klenicy Kazumy de Lima YamaguchiValdir Florêncio da Veiga-Junior
May 29, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Israel FelzenszwalbClaudia A F Aiub
Apr 29, 2014·International Journal of Cardiology·Ashley M GaleWilliam L Baker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.