In vitro and in vivo antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni

World Journal of Gastroenterology : WJG
Lin LiYang Xu

Abstract

To investigate the antioxidant and hepatoprotective effects of Cortex Dictamni aqueous extract (CDAE) in carbon tetrachloride (CCl4)-induced liver damage in rats. The in vitro antioxidant effect of CDAE was investigated using α,α-diphenyl-β-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), β-carotene bleaching, reducing power, and thiobarbituric acid reactive substance assays. A linoleic acid system, including ferric thiocyanate (FTC) and thiobarbituric acid (TBA) assays, was used to evaluate the inhibition of lipid peroxidation. The in vivo hepatoprotective and antioxidant effects of CDAE against CCl4-induced liver damage were evaluated in Sprague-Dawley rats. Silymarin was used as a positive control. Liver damage was assessed by determining hepatic histopathology and liver marker enzymes in serum. Enzyme and non-enzyme antioxidant levels and lipid peroxide content were measured in the liver. Cytochrome P450 2E1 (CYP2E1) protein expression was measured via immunohistochemical staining. Nuclear factor E2-related factor (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinine oxidoreductase 1 (NQO1), and γ-glutamylcysteine synthetase catalytic subunit (γ-GCSc) protein expression was measured by Wester...Continue Reading

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Citations

Aug 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miranda Sin-Man TsangChun-Kwok Wong
Jun 20, 2020·The Journal of International Medical Research·Lina YangDongping Ji
Oct 16, 2018·Food Science and Biotechnology·Pu Reum SeokJae-Ho Shin
Mar 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao WeiXiaoying Zhou

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Methods Mentioned

BETA
MDA
light microscopy
electrophoresis
ABTS

Software Mentioned

SPSS
ImagePro Plus
AlphaEaseFC

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