In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma

International Journal of Cancer. Journal International Du Cancer
Judit DobosAndrea Ladányi

Abstract

2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an arrest in the G(2)/M phase, and the mechanism of action involved microtubules, mitochondrial damage and caspase activation. In male SCID mice, 2ME(2) was effective in reducing primary tumor weight and the number of liver metastases after intrasplenic injection of human melanoma cells. In the metastases, we found a significantly higher rate of apoptotic cells after 2ME(2) treatment. These findings on the antitumor effect of 2ME(2) in cell culture as well as in an animal model may have implications for designing alternative treatment options for patients with advanced malignant melanoma.

References

Nov 1, 1976·Journal of the National Cancer Institute·J W ProctorL Stokowski
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·A LadányiK Lapis
Dec 1, 1990·The American Journal of Dermatopathology·C CohenD Sgoutas
Jun 1, 1980·The Journal of Investigative Dermatology·J P Neifeld, M E Lippman
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·L KopperK Lapis
Oct 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·M J WalkerC W Beattie
Apr 1, 1995·Melanoma Research·A LadányiK Lapis
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoE Hamel
Nov 12, 1996·Biochemical and Biophysical Research Communications·H AttallaL C Andersson
May 1, 1997·The British Journal of Dermatology·J G Miller, S Mac Neil
Jun 30, 1998·American Journal of Surgery·M M KemenyH R Menck
Jul 2, 1998·Biochemical and Biophysical Research Communications·H AttallaT P Mäkelä
Sep 2, 1999·British Journal of Cancer·B RichardsonS Mac Neil
Jan 1, 1996·Pathology Oncology Research : POR·Rudolf MihalikLászló Kopper
Feb 24, 2001·Cancer Metastasis Reviews·V S PribludaS J Green
Jul 27, 2001·Journal of Cancer Research and Clinical Oncology·G Schumacher, P Neuhaus
Aug 2, 2001·Biochemical and Biophysical Research Communications·L R QadanB A Roos
Aug 30, 2002·Blood·Dharminder ChauhanKenneth C Anderson
Nov 6, 2002·FEBS Letters·Shizhong BuMaréne Landström
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Xiao-Feng LiNorihisa Tonami
Jan 17, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Heike HelmbachDirk Schadendorf
Feb 18, 2003·Pharmacotherapy·Nehal J LakhaniWilliam D Figg
May 3, 2003·Cancer Cell·Nicola J MabjeeshParaskevi Giannakakou
Jun 6, 2003·Oncogene·María S Soengas, Scott W Lowe

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Citations

Mar 28, 2007·Pathology Oncology Research : POR·Judit KissAndrea Ladányi
Feb 7, 2008·Cancer Chemotherapy and Pharmacology·Samar S AzabAshraf B Abdel-Naim
Dec 4, 2012·Clinical & Experimental Metastasis·Judit DobosAndrea Ladányi
May 6, 2006·Thyroid : Official Journal of the American Thyroid Association·Pernilla RoswallNils-Erik Heldin
Aug 30, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E R KoomenT Nijsten
Mar 26, 2009·Magyar onkologia·Judit Dobos
May 11, 2011·Expert Review of Anticancer Therapy·Vincenzo de GiorgiDaniela Massi
Dec 21, 2010·Cancer Treatment Reviews·L M Davids, B Kleemann
Nov 26, 2010·Annales de chirurgie plastique et esthétique·J Schaepkens van RiempstP Schertenleib
Oct 6, 2009·International Journal of Pharmaceutics·Bin DuZhenzhong Zhang
Aug 8, 2007·International Journal of Cancer. Journal International Du Cancer·Heng-Liang LinShih-Hwa Chiou
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Tamás DeliJózsef Tímár
Apr 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yi-Chin FongSean P Scully
Jan 19, 2010·Journal of Cellular Biochemistry·Michaela B BenediktAvudaiappan Maran
May 13, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kashappa Goud H DesaiSteven P Schwendeman
Nov 12, 2016·Frontiers in Endocrinology·Monica MarzagalliPatrizia Limonta
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WangWing Shing Ho
Nov 10, 2007·Melanoma Research·Hanneke G M Wittgen, Léon C L T van Kempen
Jul 11, 2020·Cancers·Maria BellenghiGianfranco Mattia
Nov 10, 2017·Cancer Cell International·Lisa RepsoldAnnie Margaretha Joubert
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·HuiChao ZouYasuhisa Shinomura
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carolyn SidorKathy D Miller
Jul 25, 2014·Archives of Biochemistry and Biophysics·Adi Nosrati, Maria L Wei
Aug 21, 2021·Journal of Cosmetic Dermatology·Neetu BhariMohamad Goldust

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