In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy

PloS One
Renata Falchete do PradoLuana Marotta Reis de Vasconcellos

Abstract

Titanium (Ti) and Ti-6 Aluminium-4 Vanadium alloys are the most common materials in implants composition but β type alloys are promising biomaterials because they present better mechanical properties. Besides the composition of biomaterial, many factors influence the performance of the biomaterial. For example, porous surface may modify the functional cellular response and accelerate osseointegration. This paper presents in vitro and in vivo evaluations of powder metallurgy-processed porous samples composed by different titanium alloys and pure Ti, aiming to show their potential for biomedical applications. The porous surfaces samples were produced with different designs to in vitro and in vivo tests. Samples were characterized with scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and elastic modulus analyses. Osteogenic cells from newborn rat calvaria were plated on discs of different materials: G1-commercially pure Ti group (CpTi); G2-Ti-6Al-4V alloy; G3-Ti-13 Niobium-13 Zirconium alloy; G4-Ti-35 Niobium alloy; G5-Ti-35 Niobium-7 Zirconium-5 Tantalum alloy. Cell adhesion and viability, total protein content, alkaline phosphatase activity, mineralization nodules and gene expression (alkaline phosphatase...Continue Reading

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Citations

Jan 29, 2019·Journal of Materials Science. Materials in Medicine·Telmo M AndradeAnderson O Lobo
Sep 20, 2019·Journal of Materials Science. Materials in Medicine·Daphne de Camargo Reis MelloLuana Marotta Reis de Vasconcellos
Aug 18, 2020·International Journal of Biomaterials·Lais Morandini RodriguesLuana Marotta Reis de Vasconcellos
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Li LeiIlwoo Seok
Feb 4, 2021·International Journal of Nanomedicine·Ricardo Pereira NogueiraAnderson Oliveira Lobo
Oct 26, 2020·International Journal of Implant Dentistry·Daphne de Camargo Reis MelloLuana Marotta Reis de Vasconcellos

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Methods Mentioned

BETA
scanning electron microscopy
ELISA
PCR

Software Mentioned

Image J
SkyScan
NRecon
GraphPad Prism
Angle
Mode Global

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