In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems.

American Journal of Physiology. Heart and Circulatory Physiology
Obada AbouassaliSami Noujaim

Abstract

The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. Vaping, a form of electronic nicotine delivery, uses "e-liquid" to generate "e-vapor," an aerosolized mixture of nicotine and/or flavors. We report our investigation into the cardiotoxic effects of flavored e-liquids. E-vapors containing flavoring aldehydes such as vanillin and cinnamaldehyde, as indicated by mass spectrometry, were more toxic in HL-1 cardiomyocytes than fruit-flavored e-vapor. Exposure of human induced pluripotent stem cell-derived cardiomyocytes to cinnamaldehyde or vanillin-flavored e-vapor affected the beating frequency and prolonged the field potential duration of these cells more than fruit-flavored e-vapor. In addition, vanillin aldehyde-flavored e-vapor reduced the human ether-à-go-go-related gene (hERG)-encoded potassium current in transfected human embryonic kidney cells. In mice, inhalation exposure to vanillin aldehyde-flavored e-vapor for 10 wk caused increased sympathetic predominance in heart rate variability measurements. In vivo inducible ventricular tachycardia was significantly longe...Continue Reading

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Citations

Sep 16, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyZamaneh Kassiri
Oct 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Luther M SwiftNikki Gillum Posnack

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BETA
flow cytometry

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MassHunter Workstation Qualitative Analysis
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MEA Symphony
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MATLAB
PhysioTel
Ponemah

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