In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors.

Journal of Biomedical Materials Research. Part a
H E KoschwanezW M Reichert

Abstract

The purpose of this study was to test the hypothesis that porous poly-L-lactic acid (PLLA) sensor coatings reduce fibrosis and promote blood microvessel formation in tissue adjacent to the sensor surface. Porous PLLA coatings were produced using ammonium bicarbonate as the gas foaming/salt leaching agent, and deployed on functional and nonfunctional sensors. The porous coatings minimally affected sensor accuracy and response rate in vitro. Three-week subcutaneous rat studies of nonfunctional glucose sensors showed the anticipated effect of porous coatings enhancing vascularity and decreasing collagen deposition. In contrast, percutaneous functional sensors with and without porous coatings showed no significant difference in terms of histology or sensor response. In spite of the observation that texturing increases the vascularity of the tissue that surrounds implanted sensors, other factors such as the additional mechanical stresses imposed by percutaneous tethering may override the beneficial effects of the porous coatings.

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Citations

Aug 31, 2010·Analytical and Bioanalytical Chemistry·Matthew T NovakWilliam M Reichert
Jan 18, 2011·Analytical Chemistry·Scott P NicholsMark H Schoenfisch
Aug 7, 2013·ACS Applied Materials & Interfaces·Ahyeon KohMark H Schoenfisch
Dec 14, 2011·Diabetes Technology & Therapeutics·Katherine E IscoePaul A Fournier
Dec 17, 2009·Fibrogenesis & Tissue Repair·Clarice Zc Chen, Michael Raghunath
Nov 1, 2012·Sensors·Sandro CarraraGiovanni De Micheli
Feb 8, 2013·Chemical Reviews·Scott P NicholsMark H Schoenfisch
Nov 26, 2010·International Journal of Pharmaceutics·Ainhoa MuruaRosa M Hernández
Aug 16, 2015·Biosensors & Bioelectronics·Dajing ChenJohn X J Zhang
Jun 15, 2013·Journal of Biomedical Materials Research. Part a·Bo-Ji LiuXian-Zheng Sha
Jan 14, 2011·British Journal of Health Psychology·Heidi E Koschwanez, Elizabeth Broadbent
Nov 17, 2009·Journal of Biomedical Materials Research. Part a·H E KoschwanezB Klitzman
Oct 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kristan S WorthingtonEric Nuxoll
Oct 23, 2014·Tissue Engineering. Part C, Methods·Tonia C RothuizenJoris I Rotmans
Jul 30, 2014·Acta Biomaterialia·Suzana G Vallejo-HeligonWilliam M Reichert
Jul 2, 2014·Analytical Chemistry·Robert J SotoMark H Schoenfisch
Jul 3, 2015·Journal of Diabetes Science and Technology·Matthew T Novak, William M Reichert
Oct 27, 2011·Journal of Diabetes Science and Technology·Ahyeon KohMark H Schoenfisch
Nov 4, 2009·Journal of Diabetes Science and Technology·Yoshinori OnukiDiane J Burgess
Nov 4, 2009·Journal of Diabetes Science and Technology·Heidi E KoschwanezW Monty Reichert
Feb 28, 2020·Analytical and Bioanalytical Chemistry·Louis Van der MeerenAndre G Skirtach
May 23, 2017·Macromolecular Materials and Engineering·Ruochong FeiMelissa A Grunlan
Dec 12, 2017·Journal of Biomedical Materials Research. Part a·Krishna BurugapalliWenhui Song
Jan 24, 2021·Advanced Drug Delivery Reviews·Bhushan N KharbikarTejal A Desai
Dec 16, 2017·Biomaterials·Robert J SotoMark H Schoenfisch
Apr 14, 2021·ACS Biomaterials Science & Engineering·Maggie J Malone-PovolnyMark H Schoenfisch
Jan 21, 2017·Analytical Chemistry·Robert J SotoMark H Schoenfisch
Apr 9, 2018·ACS Biomaterials Science & Engineering·Pamela L GraneyKara L Spiller

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