In Vitro and In Vivo Comparative Evaluation of a Shellac-Ammonium Paclitaxel-Coated Balloon versus a Benchmark Device.

Journal of Interventional Cardiology
Congying XiaYufang Chen

Abstract

The present study was designed to compare the characteristics and performance regarding drug delivery of a novel drug-coated balloon (DCB) to a benchmark device (Restore® versus SeQuent® Please) in an in vitro and in vivo model. Although Restore® and SeQuent® are both paclitaxel-coated, they use different coating excipient, shellac-ammonium salt and iopromide, respectively. Preclinical study comparing these two different commercial DCBs regarding their characteristics and effects on early vascular response is sparse. Restore® and SeQuent® DCBs were scanned with electron microscopy for surface characteristic assessment. Both DCBs were transported in an in vitro vessel model for the evaluation of drug wash-off rate and particulate formation. Eighteen coronary angioplasties with either Restore® or SeQuent® DCBs were conducted in 6 swine (three coronary vessels each). Histopathological images of each vessel were evaluated for vessel injury. The surface of Restore® DCB was smooth and evenly distributed with hardly visible crystal, while SeQuent® DCB showed a rougher surface with relatively larger apparent crystals. Restore® DCB had a lower drug wash-off rate and fewer large visible particles, compared to the SeQuent® DCB. No signifi...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Nov 15, 2006·The New England Journal of Medicine·Bruno SchellerUlrich Speck
Dec 17, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·W SchmidtK-P Schmitz
Oct 1, 2011·International Journal of Cardiology·Bernardo Cortese, Alessandra Bertoletti
Mar 24, 2012·JACC. Cardiovascular Interventions·Bruno SchellerBodo Cremers
May 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Saami K YazdaniRenu Virmani
Jun 30, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Freek NijhoffPieter R Stella
Nov 7, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Freek NijhoffPierfrancesco Agostoni
Apr 27, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Leia HeeChristian J Mussap
Aug 3, 2017·Journal of Clinical and Diagnostic Research : JCDR·C D RamakrishnaAshok S Thakkar
Nov 27, 2013·International Journal of Cardiology. Heart & Vessels·Hee Hwa HoPaul Jau Lueng Ong
Mar 3, 2018·Cardiovascular Engineering and Technology·Emily A TurnerSaami K Yazdani
Mar 7, 2020·Journal of the American College of Cardiology·Charan YerasiRon Waksman

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