In vitro and in vivo comparison of binary Mg alloys and pure Mg

Materials Science & Engineering. C, Materials for Biological Applications
Anastasia MyrissaAnnelie-Martina Weinberg

Abstract

Biodegradable materials are under investigation due to their promising properties for biomedical applications as implant material. In the present study, two binary magnesium (Mg) alloys (Mg2Ag and Mg10Gd) and pure Mg (99.99%) were used in order to compare the degradation performance of the materials in in vitro to in vivo conditions. In vitro analysis of cell distribution and viability was performed on discs of pure Mg, Mg2Ag and Mg10Gd. The results verified viable pre-osteoblast cells on all three alloys and no obvious toxic effect within the first two weeks. The degradation rates in in vitro and in vivo conditions (Sprague-Dawley® rats) showed that the degradation rates differ especially in the 1st week of the experiments. While in vitro Mg2Ag displayed the fastest degradation rate, in vivo, Mg10Gd revealed the highest degradation rate. After four weeks of in vitro immersion tests, the degradation rate of Mg2Ag was significantly reduced and approached the values of pure Mg and Mg10Gd. Interestingly, after 4 weeks the estimated in vitro degradation rates approximate in vivo values. Our systematic experiment indicates that a correlation between in vitro and in vivo observations still has some limitations that have to be conside...Continue Reading

References

Aug 27, 2005·Biomaterials·Frank WitteHenning Windhagen
Oct 26, 2005·Biomaterials·Mark P StaigerGeorge Dias
Nov 13, 2008·Biomaterials·Xuenan GuTingfei Xi
Jun 10, 2010·Journal of Materials Science. Materials in Medicine·Z G HuanJ Duszczyk
Mar 9, 2011·Acta Biomaterialia·Regine WillumeitBoriana Mihailova
Feb 15, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jemimah WalkerGeorge J Dias
Dec 9, 2014·Acta Biomaterialia·Adela Helvia Martinez SanchezRegine Willumeit
Dec 18, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W H MaY Z Zhang

❮ Previous
Next ❯

Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Marta M AlvesMaria F Montemor
Sep 7, 2016·Journal of Biomedical Materials Research. Part a·Elmar WillboldJanin Reifenrath
Jan 24, 2017·Acta Biomaterialia·Johannes DraxlerThomas Prohaska
May 10, 2019·Biomaterials Science·Mehdi Razavi, Yan Huang
Jun 5, 2019·Materials·Aneta KaniaRafał Babilas
May 29, 2018·Innovative Surgical Sciences·Nicole Gabriele GrünAnnelie-Martina Weinberg
Aug 5, 2017·Materials·Marián VlčekRegine Willumeit-Römer
Sep 6, 2018·ChemistryOpen·Eduardo L SilvaMikhail L Zheludkevich
Mar 12, 2019·Journal of Biomaterials Applications·Yang ChenChuanzhong Chen
Nov 12, 2020·Military Medical Research·Shuai WeiXin-Long Ma
Feb 17, 2021·Journal of Biomedical Materials Research. Part a·Heike HelmholzOula Penate-Medina
May 18, 2021·Bioactive Materials·Berit Zeller-PlumhoffRegine Willumeit-Römer
Mar 12, 2018·ACS Biomaterials Science & Engineering·Jingyao WuPrashant N Kumta
Aug 22, 2021·Journal of Biomedical Materials Research. Part a·Anuradha JanaVamsi Krishna Balla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biomedical Materials Research
A B BurseR W Dykema
Physical Review. B, Condensed Matter
S H Liou, C L Chien
Physical Review. B, Condensed Matter
K W SulstonW K Liu
Revista portuguesa de estomatologia e cirurgia maxilo-facial
J Leitão, F Pereira de Melo
© 2021 Meta ULC. All rights reserved