In vitro and in vivo comparison of two different light sources for topical photodynamic therapy

The British Journal of Dermatology
Philipp BabilasR-M Szeimies

Abstract

Photodynamic therapy (PDT) with 5-aminolaevulinic acid (ALA) is an effective and safe treatment option for the treatment of actinic keratosis (AK). Incoherent lamps are often used, matching the absorption maxima of ALA. A comparative trial was performed to evaluate the efficacy of recently developed light-emitting diodes (LEDs). Human epidermal keratinocytes were incubated for 24 h with ALA (100, 200, 300, 400 or 500 micromol L(-1)) and irradiated consecutively using either an incoherent halogen lamp (lambda(em) = 580-750 nm; 24 J cm(-2); 40 mW cm(-2)) or an LED system (lambda(em) = 633 +/- 3 nm; 3, 6, 12 or 24 J cm(-2); 40 mW cm(-2)). Topical ALA-PDT was performed on 40 patients with AK (n = 584) in a symmetrical distribution suitable for two-sided comparison. After incubation with ALA (20% in cream base) irradiation was performed with the incoherent lamp (100 J cm(-2); 160 mW cm(-2)) on one side and the LED system (40 J cm(-2); 80 mW cm(-2)) on the opposite side followed by re-evaluation up to 6 months. No significant differences between the LED system (3, 6, 12 or 24 J cm(-2)) and the incoherent light source (24 J cm(-2)) regarding cytotoxicity was found in vitro. The complete remission rate yielded in the in vivo investigat...Continue Reading

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Citations

Feb 4, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P BabilasR-M Szeimies
Feb 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·Saskia LippensWim Declercq
Mar 7, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Angeles JuarranzSalvador González
Sep 11, 2012·Photodiagnosis and Photodynamic Therapy·Nobue Nakajima, Norimichi Kawashima
Mar 17, 2010·Photodiagnosis and Photodynamic Therapy·Sally H Ibbotson
Nov 21, 2009·Journal of the American Academy of Dermatology·Christine B WarrenEdward V Maytin
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Mar 8, 2008·International Journal of Pharmaceutics·Yi-Ping FangYaw-Bin Huang
Sep 1, 2007·Photodiagnosis and Photodynamic Therapy·Nick Davies, Brian C Wilson
Nov 28, 2006·Dermatologic Clinics·Jonathan E Blume, Allan R Oseroff
Nov 30, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sigrid KarrerRolf-Markus Szeimies
Jun 25, 2010·International Journal of Cosmetic Science·D HelbigU Paasch
Sep 22, 2011·The Journal of Dermatology·Toshio HasegawaShigaku Ikeda
Mar 20, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·E KohlR-M Szeimies
Jul 3, 2013·Photodermatology, Photoimmunology & Photomedicine·Evelina BuinauskaiteSkaidra Valiukeviciene
May 4, 2011·Photodermatology, Photoimmunology & Photomedicine·Sally Helen Ibbotson
Jun 30, 2010·Photodermatology, Photoimmunology & Photomedicine·Philipp BabilasRolf-Markus Szeimies
Feb 9, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Julia M SteinbauerRolf-Markus Szeimies
Jun 1, 2006·Photodiagnosis and Photodynamic Therapy·C A Morton
Mar 16, 2016·Photodiagnosis and Photodynamic Therapy·Ben NovakHermann Luebbert
Feb 3, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christine FinkPatrick Gholam
Jul 9, 2010·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Sachiko Kosaka, Seiji Kawana
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Nov 13, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Philipp BabilasRolf-Markus Szeimies
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