In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Paramita Basu, Arpita Basu

Abstract

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral n...Continue Reading

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Citations

Jul 21, 2020·Journal of Biomolecular Structure & Dynamics·Sameep SonvaneOmprakash Bhusnuare
Oct 6, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Stephanie Flore Djuichou NguemnangEgbe Ben Besong
Jul 31, 2020·International Journal of Molecular Sciences·Ramona D'AmicoRosanna Di Paola
Oct 8, 2020·Chinese Medicine·Chunhao ZhuJianqiang Yu
Jan 23, 2021·International Journal of Molecular Sciences·Marta XimenisMaría Jesús Pérez de Vega
Apr 4, 2021·Cancers·Manaal SiddiquiDietrich Büsselberg
May 8, 2021·Current Pain and Headache Reports·Prashant N RaoMark Jones

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Methods Mentioned

BETA
sedation
glycosylation
acetylation
MDA
nuclear translocation
histone acetylation

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