In vitro and in vivo effects of Laurus nobilis L. leaf extracts.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Biljana KaurinovicSanja Vlaisavljevic

Abstract

The in vitro and in vivo antioxidant activities of different extracts of laurel leaves were studied. Free radical scavenging capacity (RSC) was evaluated measuring the scavenging activity on the DPPH, NO, O(2)(.-) and OH radicals. The effects on lipid peroxidation (LP) were also evaluated. Experimental results indicate that ethyl acetate extract of leaves has exhibited the largest RSC capacity in neutralization of DPPH, NO, O(2)(.-) and OH radicals. The same result was obtained in investigation of extracts impact on LP. The in vivo effects were evaluated on some antioxidant systems (activities of GSHPx, LPx, Px, CAT and XOD, and GSH content) in the mice liver and blood-hemolysate after treatment with the examined laurel extracts, or in combination with carbon tetrachloride (CCl(4)). On the basis of the results obtained it can be concluded that the examined extracts exhibited a certain protective effect, which is more pronounced on the liver than on blood-hemolysate parameters. The results obtained indicate toxicity of CCl(4), probably due to the radicals involved in its metabolism. Combined treatments with CCl(4) and the examined extracts showed both positive and negative synergism. Based on the experimental results, the strong...Continue Reading

References

Oct 11, 1976·Biochimica Et Biophysica Acta·D T ChiuA L Tappel
Jan 1, 1991·Free Radical Biology & Medicine·G SichelR P Bonomo
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·U N DasD F Horrobin
Jan 1, 1988·Free Radical Biology & Medicine·S N Chatterjee, S Agarwal
Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Sep 25, 1998·Phytochemistry·N H FischerS G Franzblau
May 5, 1999·Current Opinion in Chemical Biology·J T Groves
Apr 11, 2001·Fitoterapia·B H BabuJ Padikkala
Mar 7, 2002·Journal of Agricultural and Food Chemistry·Alessandra CareddaCarla Soro
Jul 26, 2002·Journal of Agricultural and Food Chemistry·M Consuelo Díaz-MarotoM Dolores Cabezudo
Sep 11, 2003·Natural Product Reports·Braulio M Fraga
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Neda Mimica-DukicNatasa Simin
Feb 1, 1989·Planta medica·E Vidal-OllivierG Boudon

❮ Previous
Next ❯

Citations

Nov 16, 2011·Journal of Medicinal Food·Esam Y QnaisShtaywy S Abdalla
Dec 29, 2011·Arhiv za higijenu rada i toksikologiju·Hasan Turkez, Fatime Geyikoglu
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·I LacatusuA Meghea
Sep 12, 2015·Journal of Agricultural and Food Chemistry·Mosaab YahyaaMwafaq Ibdah
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hafize FidanValtcho D Zheljazkov
Aug 25, 2020·Biotechnology and Applied Biochemistry·Buket Bulut KocabasMelda Altikatoglu Yapaoz
Aug 31, 2017·Journal of the American College of Nutrition·Imran KhanStuart K Johnson
Feb 2, 2012·Toxicology and Industrial Health·Hasan Türkez, Başak Toğar
Mar 28, 2020·Journal of the American College of Nutrition·Chahra ChbiliMaha Ben Fredj
Feb 18, 2020·Ecotoxicology and Environmental Safety·Hanaa S S GazwiHanaa M Hassan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.