In vitro and in vivo efficacy of aqueous extract of Caryocar brasiliense Camb. to control gastrointestinal nematodes in sheep.

Parasitology Research
Flávia Aparecida NogueiraEduardo Robson Duarte

Abstract

A major problem faced in sheep rearing has been the rapid acquisition of anthelminthic-resistant populations of gastrointestinal nematodes. In the search for alternatives, aqueous extract of the peel of Caryocar brasiliense was evaluated for larval development inhibition, egg-hatching inhibition, and fecal nematode egg count reduction in sheep. For in vivo analysis, the doses were calculated according to a 10% lethal dose derived from acute toxicity tests in mice, and the efficacy was evaluated for two periods following oral administration of the extract. Egg-hatching inhibition at concentrations of 15 and 7.5 mg/ml was significantly higher than observed in negative controls with distilled water. For larval development inhibition, all concentrations showed anthelminthic activity significantly higher than controls and were not significantly different from ivermectin treatment. The LC(90) of larval development inhibition was 53.19 mg/ml. In vivo analysis for first and second weeks after treatment found 32.2% and 33% anthelminthic efficacy, respectively.

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Citations

Sep 21, 2013·Parasitology Research·Eman K A Bazh, Nasr M El-Bahy
Apr 7, 2016·Veterinary World·Ambalathaduvar MeenakshisundaramThavasi Anna
Jun 19, 2015·Tropical Animal Health and Production·Franciellen Morais-CostaEduardo Robson Duarte
Feb 2, 2017·Veterinary Research Communications·Thallyta Maria VieiraEduardo Robson Duarte
Dec 20, 2018·International Journal of Veterinary Science and Medicine·Suelen Carolina Silva SoaresRosangela da Silva de Laurentiz
Aug 23, 2018·Phytotherapy Research : PTR·Zahra GholamnezhadMohammad Hossein Boskabady
May 26, 2017·Animal : an International Journal of Animal Bioscience·C CollasG Fleurance

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.