In vitro and in vivo evaluation of a desonide gel-cream photostabilized with benzophenone-3

Drug Development and Industrial Pharmacy
Priscila RosaAndréa Inês Horn Adams

Abstract

Our group previously reported the photoinstability of some desonide topical commercial formulations under direct exposure to UVA radiation. This study aimed to prepare and characterize a gel-cream containing desonide, with greater photostability than the commercial gel-cream (C-GC). Benzophenone-3 (BP-3) was used as a photostabilizing agent. The gel-cream developed (D-GC) containing BP-3 at 0.1% was prepared and characterized regarding its pH, drug content, spreadability, viscosity, in vitro drug release and in vitro permeation. The in vivo anti-inflammatory effect was assessed by ear edema measurement, croton oil-induced acute skin inflammation and myeloperoxidase assay. D-GC presented characteristics compatible with topical application, appropriate drug content and good spreadability, and non-Newtonian behavior with pseudoplastic flow. D-GC showed a good photostability profile, presenting a desonide content of 95.70% after 48 h of exposure to UVA radiation, and stability under room conditions during 60 days. The amount of desonide released from D-GC and C-GC was 57.8 and 51.7 µg/cm(2), respectively, measured using the vertical Franz cell. The in vitro skin permeation showed that desonide reached the site of action of the topi...Continue Reading

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