In vitro and in vivo evaluation of an oral sustained release hepatoprotective caffeine loaded w/o Pickering emulsion formula - Containing wheat germ oil and stabilized by magnesium oxide nanoparticles

International Journal of Pharmaceutics
Heba ElmotasemAbeer A A Salama

Abstract

The objective of this study was to innovate an effective oral sustained release hepatoprotective formula for - the water soluble drug - caffeine. Caffeine is rapidly absorbed and eliminated which dictates frequent administration to achieve adequate therapeutic effect. A w/o Pickering emulsion incorporating caffeine in the internal phase was primed. It contained wheat germ oil and was stabilized by synthesized magnesium oxide nanoparticles (MgO NPs). Components selection was based on their antioxidant, hepatoprotective and anticarcinogenic effects. The MgO NPs were prepared via sol-gel method, and then were characterized using X-ray diffractometry, transmission electron microscopy, contact angle and cytotoxicity. The Pickering emulsion formula stabilized by MgO NPs (F1) was compared to another stabilized by conventional MgO particles (F2). Both were evaluated regarding droplet size, stability and caffeine release. F1 was stable against phase separation for a 2 months period. Its droplets mean size was 665.9 ± 90 nm. F1 afforded sustained release for caffeine that reached 70% within 48 h that followed zero order kinetics. 100 ppm of F1 showed nearly 36% growth inhibition of hepatocellular carcinoma (HEPG2). In vivo and histopatha...Continue Reading

Citations

Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haotian PanXiaodong Cao
Sep 4, 2020·Polymers·Juan Carlos Quintanilla de StéfanoAlejandro J Alvarez
Dec 23, 2020·Journal of Food Biochemistry·Seham S El-HawaryRania A El Gedaily
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Qiaomei ZhuLijun Yin
Dec 28, 2019·Toxicology Reports·Farouk K El-BazRehab A Hussein
Feb 19, 2021·Journal of Pharmaceutical Sciences·Amira Mohamed MohsenAsmaa Badawy Darwish
Feb 26, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Utkarsh BhutaniSaptarshi Majumdar

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