In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections

Antiviral Research
Debra C QuenelleEarl R Kern

Abstract

It has been reported previously that some thiosemicarbazone compounds have prophylactic activity against smallpox disease and therapeutic activity against vaccinia virus (VV) infections. In these studies, isatin-beta-thiosemicarbazone (IBT) and marboran were administered once daily by intraperitoneal (ip) injection to mice using 30, 10 or 3 mg/kg for 5 days beginning 24, 48 or 72 h after inoculation with VV or cowpox virus (CV). Both compounds were highly effective (p < 0.01) at preventing mortality due to VV even when treatment was delayed up to 72 h postinfection. In CV-infected mice, neither IBT nor Marboran were effective in preventing mortality at any dosage tested when administered at 24 h postinoculation. Viral replication in liver, spleen and kidney was delayed or reduced by 100-to 10,000-fold by 10 mg/kg of marboran, but not IBT, in VV infections. Neither compound was effective against CV infection. Neither IBT nor marboran treatment of mice cutaneously infected with VV or CV reduced viral replication or clinical disease. These results suggest that this class of compound has little therapeutic potential for orthopoxvirus infections since the in vivo activity against CV, a surrogate virus for variola, is lacking.

References

Mar 5, 2003·Antiviral Research·Robert O BakerJohn W Huggins
Mar 5, 2003·Antiviral Research·Donald F Smee, Robert W Sidwell
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Kathy A KeithEarl R Kern
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Debra C QuenelleEarl R Kern
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·Debra C QuenelleEarl R Kern
Jun 16, 2004·Antiviral Research·Debra C QuenelleEarl R Kern
Mar 22, 2005·Current Drug Targets. Infectious Disorders·Mark N Prichard, Earl R Kern
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Wendy C MageeDavid H Evans

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Citations

Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Humayun PervezM Saeed Iqbal
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Mehmet AkkurtOrhan Büyükgüngör
Aug 29, 2007·Antimicrobial Agents and Chemotherapy·Debra C QuenelleEarl R Kern
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Debra C QuenelleEarl R Kern
Jan 10, 2012·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·B A SelivanovA Ya Tikhonov
Nov 14, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Humayun PervezKhalid Mohammed Khan
Jan 18, 2011·Expert Opinion on Investigational Drugs·Aarthi NarayananKylene Kehn-Hall
Sep 1, 2007·Expert Opinion on Drug Discovery·Kamel El Omari, David K Stammers
Jul 17, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Humayun PervezKhalid Mohammed Khan
Feb 15, 2008·Bioinorganic Chemistry and Applications·Sulekh ChandraArchana Gautam
Sep 2, 2015·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Dominga RogolinoMauro Carcelli
Oct 5, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Humayun PervezKhalid Mohammed Khan
Sep 7, 2016·Journal of Biomolecular Structure & Dynamics·Mohammad ShahbazyMohsen Kompany-Zareh
Mar 13, 2012·Antiviral Research·Mark N Prichard, Earl R Kern
Jan 8, 2010·Antiviral Chemistry & Chemotherapy·Periyasamy SelvamDonald F Smee
Dec 7, 2007·Antiviral Research·Heather GreenstoneCatherine Laughlin
Mar 9, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Angela SîrbuVladimir B Arion
Apr 22, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Felix BacherVladimir B Arion
Nov 26, 2008·Antiviral Chemistry & Chemotherapy·Donald F Smee
Feb 23, 2019·The Journal of International Medical Research·Aslıhan Dilara Demir
Jan 1, 2014·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Raghu RajVipan Kumar
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eswaran RamachandranCristina Marzano
Jan 1, 2014·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Kiran GangarapuHarukuni Tokuda
Sep 24, 2015·Acta Crystallographica. Section E, Crystallographic Communications·M FathimunnisaB Sridhar
Dec 3, 2010·Journal of Medicinal Chemistry·Giorgio PelosiElisabetta Pilotti
Dec 9, 2008·Antiviral Research·Martina SpisakovaZora Melkova
Jun 12, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·B PrathimaA Varada Reddy
Aug 20, 2020·Mini Reviews in Medicinal Chemistry·Alok Kumar MoharanaBharat Bhusan Subudhi

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