In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery.

Pharmaceutical Development and Technology
Sema ArisoyBilge Pehlivanoglu

Abstract

Parkinson's disease (PD) is a neurodegenerative disease which is characterized by the loss of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD but it exhibits low oral bioavailability (30%) and very low brain uptake due to its extensive metabolism by aromatic amino acid decarboxylase in the peripheral circulation. Moreover, levodopa has psychic, gastrointestinal, and cardiovascular side effects, and most importantly, short and frequent stimulation of dopamine receptors lead to undesirable conditions such as dyskinesia over time. The challenges are to increase the therapeutic efficiency, the bioavailability and decreasing the unfavourable side effects of levodopa. Biocompatible nano-sized drug carriers could address these challenges at molecular level. For this purpose, levodopa-loaded Poly (lactide-co-glycolide) acid nanoparticles were prepared by double emulsion-solvent evaporation method for nose to brain drug delivery. Parameters such as homogenization speed, and external and internal phase content were modified to reach the highest loading efficiency. F1-1 coded formulation showed prolonged release up to 9 h. Carbodiimide method was used for surface modification studies of nanoparticl...Continue Reading

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Jul 20, 2020·Drug Delivery and Translational Research·Natália N FerreiraMaria Palmira D Gremião
Aug 28, 2020·International Journal of Molecular Sciences·Tao Ming SimDinesh Kumar Srinivasan
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Sep 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thuy Trang NguyenGiau Van Vo

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